CAS 1147459-12-8 Lauramidopropyl Dimethylamine (HCID 51392)

Overview

The CIR Expert Panel concluded that the 24 fatty acid amidopropyl dimethylamines ingredients listed below are safe in cosmetics when they are formulated to be non-sensitizing, which may be based on a QRA...Lauramidopropyl Dimethylamine...

Names & identifiers

Preferred name: Lauramidopropyl Dimethylamine
IUPAC: N-[3-(dimethylamino)propyl]dodecanamide
English name: N-[3-(DIMETHYLAMINO)PROPYL]LAURAMIDE
Molecular formula: C17H36N2O
Molecular weight: 284.48

Names & synonyms

N-[3-(dimethylamino)propyl]dodecanamideLauramidopropyl dimethylamineN-[3-(Dimethylamino)propyl]lauramideN-(3-(Dimethylamino)propyl)dodecanamideSCHERCODINE LDodecanamide, N-[3-(dimethylamino)propyl]-(LAURYLAMIDOPROPYL)DIMETHYLAMINEDTXSID8044913FS588RR72JDodecanamide, N-(3-(dimethylamino)propyl)-NSC-79892ZOHAR AMIDO AMINE L

Show more names

Lexamine L 13PKO12Einecs 221-661-3Dimethylaminopropyl lauramideLaurylamidopropylDimethylAmineN,N-DimethyllauramidopropylamineLauric 3-dimethylaminopropylamideDodecanoylamidopropyldimethylamineLauroyl(dimethyl amino propyl)amine

3-dodecanamidopropyldimethylamineDTXCID6024913DIMETHYLAMINOPROPYLLAURYLAMIDEN-(3-(Dimethylamino)propyl)lauramide1147459-12-8N,N-DIMETHYLAMINOPROPYLDODECYLAMIDEAmides, C12-18, N-(3-(dimethylamino)propyl)Amides, C12-18, N-[3-(dimethylamino)propyl]

Database identifiers

CAS: 1147459-12-8、3179-80-4
PubChem CID: 51392
DTXSID: DTXSID8044913
ChEMBL: CHEMBL3185963
UNII: FS588RR72J
EC Number: 221-661-3、689-272-5
Nikkaji: J27.687A

Properties

Computed structural properties

XLogP: 5.1
Topological polar surface area: 32.3 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 14
Heavy atoms: 20
Formal charge: 0
Complexity: 217

Experimental & physicochemical properties

Cosmetics · 3 items

Cosmetic ingredients (Lauramidopropyl Dimethylamine) -> CIR (Cosmetic Ingredient Review)

Personal care product

Antistatic

Physical DescriptionLiquid; Other Solid; CBI

Collision Cross Section181.8 Å² [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID8044913]

Physicochemical properties

Melting point: 34.5 · 34.5-38.5 °C(lit.)
Boiling point: 171 · 171-194 °C(Press: 2 Torr)
Density: 0.882 · 0.882±0.06 g/cm3(Predicted)
Flash point: 230 °F · >230 °F
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 16.29 · 16.29±0.46(Predicted)
form: Low-Melting Solid
color: White to Off-White
Cosmetics Ingredients Functions: ANTISTATIC
Cosmetic Ingredient Review (CIR): 3 · N-[3-(DIMETHYLAMINO)PROPYL]LAURAMIDE (3179-80-4)
InChI: InChI=1S/C17H36N2O/c1-4-5-6-7-8-9-10-11-12-14-17(20)18-15-13-16-19(2)3/h4-16H2,1-3H3,(H,18,20)
InChIKey: TWMFGCHRALXDAR-UHFFFAOYSA-N
SMILES: C(NCCCN(C)C)(=O)CCCCCCCCCCC
LogP: 4.561 · 4.561 (est)
Surface tension: 27.8 mN/m · 27.8mN/m at 1g/L and 20℃
EWG's Food Scores: 1 · 1-3
FDA UNII: 588 RR72J · FS588RR72J
EPA Substance Registry System: 3 · Dodecanamide, N-[3-(dimethylamino)propyl]- (3179-80-4)
UNSPSC Code: 12352100 · 12352100
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26
WGK Germany: 2 · 2
TSCA: TSCA listed
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 0.2% (1 of 653) of reports.

Danger

H302 (25.7%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P332+P317, P333+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 653 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Hazard information

Regulatory Information · 4 items

Chemical: Dodecanamide, N-[3-(dimethylamino)propyl]-

Dodecanamide, N-[3-(dimethylamino)propyl]- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Dodecanamide, N-[3-(dimethylamino)propyl]- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/10713

Dodecanamide, N-3-(dimethylamino)propyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Fatty acid amido propyl dimethylamines: Human health tier II assessment

Hazard Classes and Categories · 3 items

Acute Tox. 4 (25.7%)

Acute Tox. 4 (100%)

Skin corrosion - category 1

Toxicology

Toxicity Summary · 2 items

The CIR Expert Panel concluded that the 24 fatty acid amidopropyl dimethylamines ingredients listed below are safe in cosmetics when they are formulated to be non-sensitizing, which may be based on a QRA...Lauramidopropyl Dimethylamine...

Safe for use in cosmetics, with qualifications

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 2
tsca: TSCA listed
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
REACH Registrations: Active
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P305+P351+P338

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: Lauramidopropyl Dimethylamine

U.S. Production2023: 10,000,000 - <25,000,000 lb

Industry UsesIntermediate

Use ClassificationCosmetics -> Antistatic

General Manufacturing Information · 2 items

All Other Basic Organic Chemical Manufacturing

Dodecanamide, N-[3-(dimethylamino)propyl]-: ACTIVE

Applications

UsesN-(3-(Dimethylamino)propyl)dodecanamide is used in the study of surface chemistry and colloids as a new surfactnt for hydrate anti-agglomeration in hydrocarbon flowlines and seabed oil capture.