Basic information
- CAS
72420-38-3- Standard SMILES
CC1(c2ccccc2)OC(C(=O)O)=CC1=O- InChIKey
DFDGRKNOFOJBAJ-UHFFFAOYSA-N- Molecular formula
- C12H10O4
- Average molar mass
- 218.2 g/mol
- Monoisotopic mass
- 218.0579088
Overview
Acifran is an agonist of niacin receptors capable of mimicking niacin's ability to increase high-density lipoprotein (HDL). Acifran produces these effects at lower doses and without the skin flushing side-effects associated with niacin treatment.
Names & identifiers
- Preferred name
- Acifran
- IUPAC
- 5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
- English name
- ACIFRAN
- Molecular formula
- C12H10O4
- Molecular weight
- 218.21
Names & synonyms
ACIFRAN72420-38-3ReductolAcifranumAY-25712AY-25,712DTXSID90456855-methyl-4-oxo-5-phenylfuran-2-carboxylic acid2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-B1X701S0MVDTXCID70256852-methyl-2-phenyl-3(2H)furanone-5-carboxylic acid
Show more names
ay257124,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicaci4,5-Dihydro-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid5-methyl-4-oxo-5-phenyl-4,5-dihydro-2-furancarboxylic acid5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid(R,S)-4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
RefChem:9150414,5-dihydro-5-methy1-4-oxo-5-pheny1-2-furancarboxylic acidAcifran, (+)-Acifran, (-)-4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acidAcifran (+)-form [MI]Acifran (-)-form [MI]5-methyl-4-oxo-5-phenyl-4,5-dihydrofuran-2-carboxylic acid
Database identifiers
- CAS
72420-38-3、77103-91-4、77103-92-5
Properties
Computed structural properties
- XLogP
- 1.7
- Topological polar surface area
- 63.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 352
Physicochemical properties
- Melting point
- 176 ° · 176°
- Boiling point
- 378.4 · 378.4±42.0 °C(Predicted)
- Density
- 1.343 · 1.343±0.06 g/cm3(Predicted)
- storage temp.
- 4 °C · Store at +4°C
- solubility
- 10 mM · Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 2.25 · 2.25±0.40(Predicted)
- color
- Off-white to light yellow
- FDA UNII
- 1 X701S0MV · B1X701S0MV
- Toxicity
- 50 orally · LD50 orally in rats: 3 g/kg (Jirkovsky, 1982)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 orally in rats: 3 g/kg (Jirkovsky, 1982)
Chemistry & industry
Applications
UsesAntihyperlipopro-teinemic.
UsesAcifran is a nicotinic acid receptor agonist.
Upstream & downstream products
Upstream raw materials
Suppliers22 total
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
北京百奥创新科技有限公司15522676233 · [email protected]
台州川旭医药科技有限公司[email protected] 15165038510 · [email protected]
武汉壹加壹生物科技有限公司027-027-16602739303 16602739303 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
EMMX Biotechnology LLC
Related reactions
5 records
Compound notes
Loading…