Basic information
- CAS
1562-00-1- Standard SMILES
O=S(=O)([O-])CCO.[Na+]- InChIKey
LADXKQRVAFSPTR-UHFFFAOYSA-M- Molecular formula
- C2H5NaO4S
- Average molar mass
- 148.12 g/mol
- Monoisotopic mass
- 147.98062392
Overview
The CIR Expert Panel concluded that the 12 isethionate salts listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Sodium Isethionate...
Names & identifiers
- Preferred name
- Sodium Isethionate
- IUPAC
- sodium 2-hydroxyethanesulfonate
- English name
- Sodium isethionate
- Molecular formula
- C2H5NaO4S
- Molecular weight
- 148.11
Names & synonyms
1562-00-1SODIUM ISETHIONATEIsethionic acid sodium saltSodium 2-hydroxyethanesulfonate2-Hydroxyethanesulfonic acid sodium saltSodium hydroxyethylsulfonateEthanesulfonic acid, 2-hydroxy-, monosodium saltSodium 2-hydroxyethylsulfonateDTXSID7027413Sodium beta-hydroxyethanesulfonateSodium 2-hydroxy-1-ethanesulfonate2-Hydroxyethanesulfonic acid, sodium salt
Show more names
2-HYDROXYETHANESULFONIC ACIDphonic acid2-HydroxyethanesuLISETHIONIC ACID SODIUM2-hydroxyethyl sulfonateSodiumhydroxyethylsulfonateHYDROXYETHYLSULFONIC ACID SODIUM SALT
3R36J71C17DTXCID007413NSC-124283RefChem:183946216-343-6sodium;2-hydroxyethanesulfonateC2H5NaO4SMFCD00007534
Database identifiers
- CAS
1562-00-1
Properties
Computed structural properties
- Topological polar surface area
- 85.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 121
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Biocides/Disinfectants
Cosmetics
Cosmetic ingredients (Sodium Isethionate) -> CIR (Cosmetic Ingredient Review)
Hair conditioning; Cleansing; Skin conditioning; Antistatic
Food Contact SubstancesFCS -> FDA Cumulative Estimated Daily Intake (CEDI)
Physical Description
Liquid
White crystalline powder; [MSDSonline]
Physicochemical properties
- Melting point
- 191 · 191-194 °C(lit.)
- Density
- 1762.7 · 1762.7[at 20℃]
- bulk density
- 800 kg/m3 · 800kg/m3
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- 2 O: · H2O: 0.1 g/mL, clear, colorless
- form
- Fine Powder
- color
- White
- PH
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 99.3% (147 of 148) of all reports.
Not Classified
Aggregated GHS information provided per 148 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: Ethanesulfonic acid, 2-hydroxy-, monosodium salt
Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 02-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13420
Ethanesulfonic acid, 2-hydroxy-, monosodium salt: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryOral LD50 (rat) >5,000 mg/kg; Not irritating in acute eye irritation testing; [IUCLID] An irritant; [MSDSonline]
Hazard Classes and CategoriesNot Classified
Toxicology
Toxicity Summary
The CIR Expert Panel concluded that the 12 isethionate salts listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Sodium Isethionate...
Safe for use in cosmetics, with qualifications
Non-Human Toxicity Excerpts
PERFUSION OF THE ISOLATED SPINAL CORD OF THE FROG WITH SODIUM ISETHIONATE DID NOT AFFECT THE RESPONSES OF THE EXTRACELLULAR POTASSIUM, BUT IT DID AFFECT THE NEURONAL MEMBRANES.
Chemistry & industry
Uses & manufacturing
Uses
CIR ingredient: Sodium Isethionate
Used for wetting coal dust and as a sulfoethylating agent in organic synthesis; [HSDB] Used in cleaning/washing agents, disinfectants, cosmetics, surface-active agents, shampoos, and bubble baths; [IUCLID]
Using Disinfectants or Biocides [Category: Clean]
IN COMPOSITION FOR WETTING COAL DUST
CHEM INT FOR ACYL ISETHIONATES USED IN DETERGENTS & SOAPS
SULFOETHYLATING AGENT IN ORG SYNTH
U.S. Exports
(1979) No Data
(1981) No Data
U.S. Imports
(1979) No Data
(1981) No Data
U.S. Production
2023: 25,000,000 - <40,000,000 lb
(1977) AT LEAST 1.36X10+9 GRAMS
(1981) No Data
Consumer UsesSurfactant (surface active agent)
Industry UsesIntermediate
Methods of ManufacturingPROBABLY BY REACTION OF 2-CHLOROETHYLSULFONIC ACID WITH SODIUM HYDROXIDE; PROBABLY BY REACTION OF ETHYLENE OXIDE WITH SODIUM BISULFITE
Household ProductsInformation on 60 consumer products that contain Sodium isethionate in the following categories is provided:
Use ClassificationCosmetics -> Hair conditioning; Cleansing; Skin conditioning; Antistatic
General Manufacturing Information
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1): ACTIVE
Related reactions
6 records
Compound notes
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