Basic information
- CAS
1302-78-9- Standard SMILES
O.O=[Si]=O.[O]=[Al][O][Al]=[O]- InChIKey
SVPXDRXYRYOSEX-UHFFFAOYSA-N- Molecular formula
- Al2H2O6Si
- Average molar mass
- 180.06 g/mol
Overview
Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visible on the skin.
Names & identifiers
- Preferred name
- Quaternium 18-bentonite
- IUPAC
- dioxosilane;oxo(oxoalumanyloxy)alumane;hydrate
- English name
- Bentonite
- Molecular formula
- Al2O3.4(SiO2).H2O
- Molecular weight
- 360.31
Names & synonyms
BentoquatamQuaternium 18-bentoniteOrganoclayClaytone soTixogel mpTixogel te1340-69-8Claytone 40RefChem:930441TIXOGEL MP-100DTXSID3010274287F465U79Q1
Show more names
MONTMORILLONITECI 77004FULLERS EARTHvolclaytixotonpengruntuBENTONITE MAGMAMONTMORILLONITECLAY
dimethyldioctadecylammonium montmorilloniteBentone 34Bentonite NanoclayBentone 27HI-Jelaluminosilicate hydrateBentonite [JAN:NF]Bentonite, sodium form
Database identifiers
- CAS
1302-78-9、1340-69-8- PubChem CID
- 517273
- ChEMBL
CHEMBL1201446- EC Number
- 932-858-5
Properties
Computed structural properties
- Topological polar surface area
- 78.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 0
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 52.4
Experimental & physicochemical properties
SolubilitySoluble
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Density
- 2 · 2~3g/cm3
- storage temp.
- Store at room temperature, keep dry and cool
- solubility
- Practically insoluble in water and in aqueous solutions. It swells with a little water forming a malleable mass.
- form
- powder
- color
- Light yellow or green, cream,pink, gray to black solid
- Odor
- odorless, sl. earthy taste
- Water Solubility
- Insoluble in water and forms a colloidal solution.
- Merck
- 14 · 14,1055
- Exposure limits
- 1 mg/m3 · ACGIH: TWA 1 mg/m3
- Dielectric constant
- 8.1 · 8.1(Ambient)
- Stability
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (36 of 36) of all reports.
Not Classified
Aggregated GHS information provided per 36 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: Quaternium 18-bentonite
Tixogel VP: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Quaternium 18-bentonite: Human health tier I assessment
Hazard Classes and CategoriesNot Classified
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- CT9450000
- Toxicity
- LD50 intravenous in rat: 35mg/kg
- risk_code
- 20/22-8
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H319-H315-H335
Chemistry & industry
Pharmacology
Pharmacodynamics
Bentoquatam protects the skin like a shield against poison ivy, poison oak, and poison sumac by physically blocking skin contact with their resin. The best protection against getting these conditions is to avoid contact with these plants. This medicine does not dry oozing and weeping caused by the rash of poison ivy, poison oak, or poison sumac.
Mechanism of Action
The mechanism of action is unknown. It is thought topically applied bentoquatam acts as a physical barrier that interferes with the adsorption of antigens onto the skin and reduces absorption of antigens into the skin. It probably does not work by modifying the systemic allergic response.
MeSH Pharmacological ClassificationDrugs used to treat or prevent skin disorders or for the routine care of skin.
Applications
DescriptionBentonite is a light yellow, creamy, palebrown or gray to black powder or granules. These chemicals contain 1- 24% crystalline silica (O2Si). Specificgravity (H2O:1)=2.5. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Insoluble in water
UsesAs of Fuller's earth; as emulsifier for oils; as a base for plasters. Pharmaceutic aid (suspending agent).
Usesfiller in cosmetics and other products, gel, or solid if dry
Usesbentonite (bentonite clay) is used to regulate the viscosity and suspension properties of a cosmetic formulation. It also acts as an overall formula stabilizer. Bentonite’s water-absorption capabilities allow it to form a gelatinous mass. Considered a noncomedogenic raw material, bentonite is a colloidal aluminum silicate clay.
UsesBentonite is a general purpose additive that is used as a pigment and colorant and to clarify and stabilize wine.
General DescriptionBentonite is comprised primarily of the smectite group (montmorillonite) of clay minerals. It is widely used in various industrial applications such as clarification of edible and mineral oils, paints, cosmetics, and pharmaceuticals. It is also used as an adsorbent for the elimination of pollutants from wastewater. The swelling property of bentonite is used to produce viscous water suspensions for bonding, plasticizing, and suspending applications. The presence of a large surface area of bentonite is due to the colloidal dispersion of the particles is the main reason for its application as an insecticide carrier, an emulsifier, and an emulsion stabilizer.
Related reactions
2 records
Compound notes
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