Basic information
- CAS
38937-66-5- Standard SMILES
O=C(CCCCCCC(=O)NO)NO- InChIKey
IDQPVOFTURLJPT-UHFFFAOYSA-N- Molecular formula
- C8H16N2O4
- Average molar mass
- 204.22 g/mol
- Monoisotopic mass
- 204.111007
Overview
N,N'-dihydroxyoctanediamide is a hydroxamic acid.
Names & identifiers
- Preferred name
- Suberohydroxamic acid
- IUPAC
- N,N'-dihydroxyoctanediamide
- English name
- Suberohydroxamic acid
- Molecular formula
- C8H16N2O4
- Molecular weight
- 204.22
Names & synonyms
Suberohydroxamic acidRefChem:109911938937-66-5sbhaN1,N8-Dihydroxyoctanediamiden,n'-dihydroxyoctanediamideSuberoyl bis-hydroxamic acidSuberodihydroxamic AcidMFCD00192455Suberic BishydroxamateCHEMBL320497N,N'-bis(oxidanyl)octanediamide
Show more names
ODHASoft oxime[PTYR705]-STAT3STAT3 (PTYR705)SuberohydroxaMic acid 95%SuberoylBis-hydroxamicAcisuberic bishydroxamic acid
SuberoylBis-hydroxamicAcidOctanedioic acid bis-hydroxyamideSuberoic bis hydroxamic acidSuberoyl bis hydroxamic acidEAQ6ZJ2V32Suberohydroxamic acid, 95%N,N inverted exclamation marka-Dihydroxyoctanediamideorb1218077
Database identifiers
- CAS
38937-66-5- PubChem CID
- 5173
- DTXSID
DTXSID801372137- ChEMBL
CHEMBL320497- ChEBI
Properties
Computed structural properties
- XLogP
- -0.5
- Topological polar surface area
- 98.7 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 164
Physicochemical properties
- Melting point
- 153 · 153-155 °C(lit.)
- Density
- 1.219 · 1.219±0.06 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- 2 O: · H2O: soluble
- pka
- 9.18 · 9.18±0.20(Predicted)
- form
- lyophilized powder
- color
- White to Light Beige
- Stability
- Hygroscopic
- InChI
- 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
- InChIKey
- IDQPVOFTURLJPT-UHFFFAOYSA-N
- SMILES
- ONC(=O)CCCCCCC(=O)NO
- UNSPSC Code
- 51111800 · 51111800
- NACRES
- 77 · NA.77
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
- HS Code
- 2928009090 · 2928009090
- Storage Class
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- hs_code
- 2928009090
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
DescriptionSuberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
UsesInhibits histone deacetylation.
UsesHistone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Suppliers64 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
南京予善化工有限公司025-025-85281586 +86-18105181009 · [email protected]
Hebei Zhuanglai Chemical Trading Co Ltd+86-16264648883 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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