Basic information
- CAS
2836-32-0- Standard SMILES
O=C([O-])CO.[Na+]- InChIKey
VILMUCRZVVVJCA-UHFFFAOYSA-M- Molecular formula
- Na-C2-H3-O3
- Average molar mass
- 98.03 g/mol
- Monoisotopic mass
- 97.99798824
Overview
Sodium glycolate is an organic sodium salt comprising equal numbers of sodium and glycolate ions. It has a role as a keratolytic drug. It contains a glycolate.
Names & identifiers
- Preferred name
- Sodium Glycolate
- IUPAC
- sodium 2-hydroxyacetate
- English name
- Sodium glycolate
- Molecular formula
- C2H3NaO3
- Molecular weight
- 98.03
Names & synonyms
Sodium glycolate2836-32-0Sodium 2-hydroxyacetateSodium hydroxyacetateSodium glycollateMonosodium glycolateSodium lycolateNatriumglykolatGlykokolan sodnyGlycolic acid, monosodium saltGLYCOLIC ACID, SODIUM SALTHydroxyacetic acid, monosodium salt
Show more names
sodiumlycolateglykokolansodnySodiumglycollateSodiuM glycollatmonosodiumglycolateGlycolic acidSodiumSodium glycolate,97%
B75E535IMICHEBI:132094RefChem:887550220-624-9Glycolic Acid Sodium SaltAcetic acid, hydroxy-, monosodium saltsodium;2-hydroxyacetateC2H3NaO3
Database identifiers
- CAS
2836-32-0- PubChem CID
- 517347
- DTXSID
DTXSID6047153- ChEBI
CHEBI:132094- UNII
- B75E535IMI
Properties
Computed structural properties
- Topological polar surface area
- 60.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 44.1
Experimental & physicochemical properties
Chemical ClassesMetals -> Organic Acids, Metal Salts
CosmeticsCosmetic ingredients (Sodium Glycolate) -> CIR (Cosmetic Ingredient Review)
Food Contact SubstancesFCS -> FDA Cumulative Estimated Daily Intake (CEDI)
Physical Description
Liquid; CBI; Dry Powder
White lumpy powder; [Alfa Aesar MSDS]
Physicochemical properties
- Melting point
- 210 · 210-218℃
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2-8°C
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble
- Cosmetics Ingredients Functions
- BUFFERING
- InChI
- InChI=1S/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1
- InChIKey
- VILMUCRZVVVJCA-UHFFFAOYSA-M
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 33.5% (92 of 275) of reports.
Danger
H315 (66.5%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 275 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Acetic acid, hydroxy-, monosodium salt
Acetic acid, 2-hydroxy-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-hydroxy-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Sodium glycollate: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Causes zonal hepatitis, changes primarily in glomeruli, and changes in the spleen in oral lethal-dose studies of mice; Causes changes in renal tubules and weight loss in oral studies of rats; [RTECS] May cause irritation; [Alfa Aesar MSDS] See Glycolic acid.
Hazard Classes and CategoriesSkin Irrit. 2 (66.5%)
Safety & protection
Protective Action Criteria (PAC)
21 [mg/m3]
230 [mg/m3]
1400 [mg/m3]
Toxicology
Chemistry & industry
Pharmacology
Metabolism/Metabolites
The main path of the degradation of glycolic acid is to glyoxylic acid. This reaction is mediated by lactic dehydrogenase or glycolic acid oxidase. Once glyoxylic acid is formed, it is apparently degraded very rapidly to a variety of products, a few of which have been observed. Its breakdown to 2-hydroxy-3-oxoadipate it is thought, is mediated by thiamine pyrophosphate in the presence of magnesium ions. The formation of glycine involves pyridoxal phosphate and glyoxylate transaminase, whereas the formation of carbon dioxide and water via formic acid apparently involves coenzyme A (CoA) and flavin mononucleotides. (T29)
MeSH Pharmacological ClassificationAgents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
Uses & manufacturing
Uses
CIR ingredient: Sodium Glycolate
Formerly registered in the US for use as a hard surface disinfectant/sanitizer; [FDA] Used as a buffer in electroless plating and textile finishing; [Alfa Aesar MSDS] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
Electroplating [Category: Plate]
Due to its excellent capability to penetrate skin, glycolic acid finds applications in skin care products, most often as a chemical peel. It may reduce wrinkles, acne scarring, hyperpigmentation and improve many other skin conditions, including actinic keratosis, hyperkeratosis, and seborrheic keratosis. Glycolic acid is also a useful intermediate for organic synthesis and finds employment in the textile industry as a dyeing and tanning agent, in food processing as a flavoring agent and as a preservative. Glycolic acid is often included into emulsion polymers, solvents and additives for ink and paint in order to improve flow properties and impart gloss. (L1909)
U.S. Production2023: 400,000 - <550,000 lb
Consumer Uses
Related reactions
8 records
Compound notes
Loading…