Basic information
- CAS
287383-59-9- Standard SMILES
O=C(CCCCCN1C(=O)c2cccc3cccc(c23)C1=O)NO- InChIKey
JTDYUFSDZATMKU-UHFFFAOYSA-N- Molecular formula
- C18H18N2O4
- Average molar mass
- 326.3 g/mol
- Monoisotopic mass
- 326.12665706
Overview
6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.
Names & identifiers
- Preferred name
- Scriptaid
- IUPAC
- 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
- English name
- SCRIPTAID
- Molecular formula
- C18H18N2O4
- Molecular weight
- 326.35
Names & synonyms
scriptaid287383-59-9GNF-PF-20246-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamideEJQ8CD8BSV1h-benz[de]isoquinoline-2(3h)-hexanamide, n-hydroxy-1,3-dioxo-N-Hydroxy-1,3-dioxo-1H-benz(de)isoquinoline-2(3H)-hexan amideDTXSID702744581H-BENZ(DE)ISOQUINOLINE-2(3H)-HEXANAMIDE, N-HYDROXY-1,3-DIOXO-6-(1,3-dioxobenzo(de)isoquinolin-2-yl)-N-hydroxyhexanamideRefChem:931493DTXCID40225937
Show more names
CS-1136GCK 1026Scriptaid (GCK1026)Scriptaid, ScriptideScriptaid, 10 mM in DMSOScriptaid, HDAC inhibitorGCK 1026GCK1026GCK-1026
Scriptide6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamideScriptide;GCK1026UNII-EJQ8CD8BSVMFCD00386477CHEMBL96051SB-556629N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexananmide
Database identifiers
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 86.7 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 477
Physicochemical properties
- Melting point
- 160 · 160-161 °C
- Density
- 1.338 · 1.338±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO (up to 4 mg/ml).
- form
- Yellow solid.
- pka
- 9.46 · 9.46±0.20(Predicted)
- color
- White
- biological source
- synthetic (organic)
- Sensitive
- Light Sensitive
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- InChI
- InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
- InChIKey
- JTDYUFSDZATMKU-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C3C(C=CC=C3C(=O)N1CCCCCC(NO)=O)=CC=C2
- FDA UNII
- 8 CD8BSV · EJQ8CD8BSV
- UNSPSC Code
- 12352203 · 12352203
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationCompounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
Applications
DescriptionScriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.
UsesScriptaid has been used in post activation of oocytes and embryo culture.
UsesHistone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.
General DescriptionScriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.
Suppliers100 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
Related reactions
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Compound notes
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