O-Methylhydroxylamine hydrochloride
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Basic information
- CAS
593-56-6- Standard SMILES
CON.Cl- InChIKey
XNXVOSBNFZWHBV-UHFFFAOYSA-N- Molecular formula
- CH6ClNO
- Average molar mass
- 83.52 g/mol
- Monoisotopic mass
- 83.0137915
Names & identifiers
- Preferred name
- O-Methylhydroxylamine hydrochloride
- IUPAC
- O-methylhydroxylamine;hydrochloride
- English name
- Methoxyamine Hydrochloride
- Molecular formula
- CH5NO.ClH
- Molecular weight
- 83.52
Names & synonyms
593-56-6O-METHYLHYDROXYLAMINE HYDROCHLORIDEMethoxyamine hydrochlorideMethoxylamine hydrochloridemethoxyamine HClMethoxyammonium chloride(aminooxy)methane hydrochlorideMethyloxyammonium chlorideMethoxyamine, hydrochlorideNSC-3801Hydroxylamine methyl ether hydrochloride203546OLMF
Show more names
MAHMETHYLHYDROXYLAMINE HYDROCHLORIDEO-METHOXYAMINE HCLO-METHYLHYDROXYLAMINE HCLO-Methoxylamine Hydrochloride
DTXSID9025615NSC3801TRC-102RefChem:157068DTXCID005615TRC 102209-798-7MFCD00012951
Database identifiers
- CAS
593-56-6- PubChem CID
- 521874
- DTXSID
DTXSID9025615- ChEMBL
CHEMBL1609430- UNII
- 203546OLMF
- EC Number
- 209-798-7
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 35.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Formal charge
- 0
- Complexity
- 4
Experimental & physicochemical properties
SolubilitySoluble (NTP, 1992)
Melting Point300 to 304 °F (decomposes) (NTP, 1992)
Physical Description
O-methylhydroxylamine hydrochloride appears as off-white crystals. (NTP, 1992)
Off-white solid; [CAMEO] Colorless hygroscopic solid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 151 · 151-154 °C(lit.)
- Boiling point
- 105 · 105-110°C
- Density
- 1.1 g/mL · 1.1 g/mL at 25 °C
- refractive index
- 20 · n20/D 1.4021
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- alcohol: soluble(lit.)
- form
- Crystalline Powder
- color
- White to very faint yellow
- Water Solubility
- SOLUBLE
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302+H312 (46.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]；H302 (76.4%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (75.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H314 (26.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (27.1%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (80%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H318 (73.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H351 (74.2%): Suspected of causing cancer [Warning Carcinogenicity]；H372 (27.1%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H373 (52%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]；H400 (98.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H412 (71.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P203, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 225 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: Hydroxylamine, O-methyl-, hydrochloride
Chemistry & industry
Uses & manufacturing
UsesUsed as an analytical reagent for aldehydes and ketones; [NTP]
General Manufacturing InformationHydroxylamine, O-methyl-, hydrochloride (1:1): ACTIVE
Applications
DescriptionMethoxamine hydrochloride, also known as methoxamine hydrochloride, O-methyl hydroxylamine hydrochloride. It is a white crystalline powder, and its fusing point is 149 ~ 152°C, soluble in water, dissolved in alcohol, insoluble in ether and toluene, etc., and the solution is in acid. Methoxamine hydrochloride is an important chemical and medicine intermediate, can be used for the development and printing of color photography and film, and is widely used in the synthesis of medicine, functional dye, low-toxin farm chemicals, and new herbicides. Methoxamine hydrochloride is mainly used in the synthesis of s-generation cephalosporin product cephalofruxin in medical, and sulfamethoxazole; alkynes promise are bright, the synthesis of hydroxyurea, etc.; Agricultural chemicals aspect is then mainly used in the kresoxim-methyl of synthesizing efficient low toxicity.
Usesantineoplastic, hydroxymethyltransferase inhibitor
UsesMethoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry
UsesMethoxylamine hydrochloride is used as a reagent in the preparation of O-methyl oximes from aldehydes. It is orally bioavailable small molecule inhibitor with potential adjuvant activity. It is also used as internal standard for prostaglandin assays by gas chromatography-mass spectrometry.
General DescriptionOff-white crystals.
Upstream & downstream products
Upstream raw materials
Related reactions
1,213 records
Compound notes
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