CAS 74517-78-5 Indecainide (HCID 52195)

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Basic information

CAS: 74517-78-5
Standard SMILES: CC(C)NCCCC1(C(N)=O)c2ccccc2-c2ccccc21
InChIKey: UCEWGESNIULAGX-UHFFFAOYSA-N
Molecular formula: C20H24N2O
Average molar mass: 308.4 g/mol
Monoisotopic mass: 308.18886339

Overview

Indecainide is a member of fluorenes.

Names & identifiers

Preferred name: Indecainide
IUPAC: 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
English name: 9[3[(1methylethyl)amino]propyl]-fluorene-9-carboxamide
Molecular formula: C20H24N2O
Molecular weight: 308.41736

Names & synonyms

INDECAINIDE74517-78-5IndecainidaIndecainidumDTXSID20578193AZF20DM1TDTXCID30316089-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboxamide9-(3-((1-methylethyl)amino)propyl)-9H-fluorene-9-carboxamide9-(3-((propan-2-yl)amino)propyl)-9H-fluorene-9-carboxamideRefChem:148111Ricainid

Show more names

Ccris 2655

RicainideIndecainidum [Latin]Indecainida [Spanish]Indecainide [INN]9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide9-(3-(Isopropylamino)propyl)-9H-fluorene-9-carboxamide

Database identifiers

CAS: 74517-78-5
PubChem CID: 52195
DTXSID: DTXSID2057819
ChEMBL: CHEMBL1201242
ChEBI: CHEBI:135314
UNII: 3AZF20DM1T
Nikkaji: J32.491D

Properties

Computed structural properties

XLogP: 3
Topological polar surface area: 55.1 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 6
Heavy atoms: 23
Formal charge: 0
Complexity: 398

Experimental & physicochemical properties

DrugsPharmaceuticals -> Listed in ZINC15

LogP3.8

Solubility8.96e-04 g/L

Melting Point · 2 items

94-95 °C

94 - 95 °C

Physical DescriptionSolid

Physicochemical properties

Melting point: 94 · 94-95°
FDA UNII: 3 AZF20DM1T · 3AZF20DM1T

Chemistry & industry

Pharmacology

Pharmacodynamics · 1 item

Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Mechanism of ActionIndecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Absorption, Distribution and ExcretionNearly complete following oral administration.

Cellular LocationsMembrane