HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide
Sodium iodine · Hydriodic acid sodium salt · Soiodin · Anayodin · ioduredesodium · Sodium monoiodide · Sodium iodide (NaI) · Sodium iodide hydrate
Identifiers & Physical Properties
| CAS No. | 7681-82-5 |
|---|---|
| Molecular formula | INa |
| Average molar mass | 149.8942 g/mol |
| Monoisotopic mass | 149.89424 g/mol |
| SMILES | [I-].[Na+] |
| InChIKey | FVAUCKIRQBBSSJ-UHFFFAOYSA-M |
| PubChem CID | 5238 |
| ChEMBL | CHEMBL1644695 |
| ChEBI | CHEBI:33167 |
| EC No. | 231-679-3 |
| DTXSID | DTXSID2041125 |
Chemical & Physical Properties
| Topological polar surface area | 0 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 1 |
| Rotatable bonds | 0 |
| Heavy atoms | 2 |
| Formal charge | 0 |
| Complexity | 2 |
| pH | 8-9.56-9 (50g/l, H2O, 20℃) |
| Odor | ODORLESS |
| Taste | SALINE, SOMEWHAT BITTER TASTE |
| Density | 3.673.67 g/cm³3.667 @25 °C |
| Color/Form | COLORLESS, CUBIC CRYSTALSWHITE CRYSTALS OR GRANULESWHITE POWDER |
| Solubility | SolubleSOLUBILITY (G/100 CC SOLVENT): 184 G IN WATER @ 25 °C302 G IN WATER @ 100 °C42.57 G IN ALCOHOL @ 25 °C39.9 G IN ACETONE @ 25 °C1 G SOL IN 1 ML GLYCEROLSolubility in water, g/100ml at 25 °C: 184water: soluble(lit.)184 g/100 mL (25 ºC) |
| Boiling point | Decomposes1304 °C1304 °C @760 [mm Hg]1300 °C |
| Melting point | 651651 °C660 °C661 °C (lit.) |
| Vapor pressure | 1 MM HG @ 767 °C1 [mm Hg] @767 °C1 hPa (767 °C) |
| Refractive index | INDEX OF REFRACTION: 1.7745 |
| Physical Description | LiquidCBIDry PowderWet SolidWhite odorless deliquescent solidTurned brown by air[Merck Index] Colorless to white hygroscopic solid[ICSC] White odorless crystalline powder[MSDSonline]COLOURLESS-TO-WHITE HYGROSCOPIC CRYSTALS OR WHITE POWDER. TURNS BROWN ON EXPOSURE TO AIR. |
| Stability/Shelf Life | IT IS MADE SLIGHTLY ALKALINE TO RENDER IT MORE STABLE |
| Bulk density | 1500-2000kg/m3 |
| Vapor density | >1 (vs air) |
| Flash point | 1300-1304°C |
| Storage conditions | Store at +5°C to +30°C. |
| pKa (acidity coefficient) | 0.067[at 20 ℃] |
| Physical state | beads |
| Specific gravity | 3.67 |
| Color | White |
| Specific heat capacity | Cp(crystal): 0.35 J/(g·K), at 25℃ |
| Sensitivity | Hygroscopic |
| Merck | 14,8631 |
| Dielectric constant | 7.2800000000000002 |
| Stability | hygroscopic |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | 1S/HI.Na/h1H/q+1/p-1 |
| InChIKey | FVAUCKIRQBBSSJ-UHFFFAOYSA-M |
| SMILES | [Na+].[I-] |
| LogP (partition coefficient) | -1.301 at 25℃ |
| CAS DataBase Reference | 7681-82-5(CAS DataBase Reference) |
| Indirect Additives used in Food Contact Substances | SODIUM IODIDE |
| FDA 21 CFR | 178.1010 |
| EWG's Food Scores | 1 |
| FDA UNII | F5WR8N145C |
| NIST Chemistry Reference | Sodium iodide(7681-82-5) |
| EPA Substance Registry System | Sodium iodide (7681-82-5) |
| UNSPSC Code | 12352302 |
| NACRES | NB.22 |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H315-H319-H372-H400 |
| GHS precautionary statements | P260-P264-P273-P302+P352-P305+P351+P338-P314 |
| Hazard symbols | Xi,N |
| Risk statements (R) | 36/38-36/37/38-50 |
| Safety statements (S) | 26-61 |
| UN transport number | UN 3077 9 / PGIII |
| Water hazard class (WGK) | 1 |
| RTECS number | WB6475000 |
| F | 8 |
| TSCA inventory status | TSCA listed |
| Hazard class | 9Eye Irrit. 2 |
| Customs code | 28276000 |
| Storage class | 13 - Non Combustible Solids |
| Hazardous substances data | 7681-82-5(Hazardous Substances Data) |
| Toxicity | MLD i.v. in rats: 1.3 g/kg, Loeser, Konwiser, J. Lab. Clin. Med. 15, 35 (1929) |
| REACH registrations | Active |
| Limited quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 7.9% (39 of 495) of reports.DangerH315 (70.9%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (72.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (16.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H372 (42.8%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]H400 (61.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H411 (10.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P260, P261, P264, P264+P265, P270, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 495 reports by companies from 36 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 39 of 495 reports by companies.There are 35 notifications provided by 456 of 495 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatory information | Chemical: Sodium iodide (NaI)Sodium iodide (NaI) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sodium iodide (NaI) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 05-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5959Status: Active Update: 12-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/5847Status: Active Update: 18-02-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/25025Sodium iodide: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Sodium iodide (NaI): Human health tier I assessmentIMAP assessments - Sodium iodide (NaI): Environment tier I assessment |
| Fire hazards | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Fire potential | PERCHLORIC ACID IGNITES IN CONTACT WITH SODIUM IODIDE. |
| Hazards summary | A skin, eye, and respiratory tract irritantIf ingested: the substance may have effects on the thyroid and may cause systemic sensitization. Symptoms of systemic sensitization may include airway obstruction and various skin reactions or even anaphylactic shock. Exposure during pregnancy may affect the thyroid function of the newborn. [ICSC] An irritant[MSDSonline] See Iodine for the TLV of Iodides. |
| Chemical Dangers | Reacts violently with strong oxidants. This produces iodine fumes. |
| Hazard Classes and Categories | Skin Irrit. 2 (70.9%)Eye Irrit. 2 (72.7%)STOT SE 3 (16.8%)STOT RE 1 (42.8%)Aquatic Acute 1 (61.8%)Aquatic Chronic 2 (10.1%) |
| State drinking water guidelines | (ME) MAINE 340 ug/l /Iodide ion/ |
| Fire fighting | In case of fire in the surroundings, use appropriate extinguishing media. |
| First aid measures | Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . |
| Safe storage | Separated from strong oxidants and food and feedstuffs. Dry. Well closed. |
| Storage conditions | KEEP WELL CLOSED & PROTECTED FROM LIGHT. |
| Spillage disposal | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. |
| Eye Prevention | Wear safety goggles or eye protection in combination with breathing protection if powder. |
| Inhalation Risk | A harmful concentration of airborne particles can be reached quickly , especially if powdered. |
| Skin Prevention | Protective gloves. |
| Exposure Prevention | PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF (PREGNANT) WOMEN! |
| Ingestion Prevention | Do not eat, drink, or smoke during work. |
| Inhalation Prevention | Use ventilation (not if powder), local exhaust or breathing protection. |
| Threshold Limit Values (TLV) | 0.01 [ppm], inhalable fraction and vapor (iodides)0.01 ppm as TWAA4 (not classifiable as a human carcinogen). |
| Interactions | ...LITHIUM CARBONATE THEORETICALLY COULD INTERACT WITH...SODIUM IODIDE. |
| Exposure routes | The substance can be absorbed into the body by ingestion. |
| Signs and Symptoms | Cough. Sore throat. Headache.Redness.Diarrhoea. Nausea. Vomiting. |
| Human Toxicity Excerpts | THE OCCASIONAL USE OF IODIDES FOR ASTHMA IN PREGNANCY HAS RESULTED IN FETAL DEATH, SEVERE GOITER & CRETINOID APPEARANCE OF THE NEWBORN. /IODIDE SALTS/..."IODISM" RESULTS FROM CHRONIC IODIDE OVERDOSES... IODISM IS CHARACTERIZED BY SALIVATION, CORYZA, SNEEZING, CONJUNCTIVITIS, HEADACHE, FEVER, LARYNGITIS, BRONCHITIS, STOMATITIS, PAROTITIS...&...EDEMA OF GLOTTIS...HAS OCCURRED. /IODIDE SALTS/TEN GRAMS OF SODIUM IODIDE HAVE BEEN GIVEN SLOWLY BY IV ROUTE WITHOUT ILL EFFECTS.OCCASIONAL INDIVIDUALS SHOW...SENSITIVITY TO IODIDE OR TO ORG PREPN THAT CONTAIN IODINE WHEN...ADMIN IV. ONSET OF AN ACUTE REACTION MAY OCCUR IMMEDIATELY OR SEVERAL HR AFTER ADMIN. ANGIOEDEMA IS OUTSTANDING SYMPTOM, & SWELLING OF LARYNX MAY LEAD TO SUFFOCATION. MULTIPLE CUTANEOUS HEMORRHAGES MAY BE PRESENT. /IODIDE PREPN/For more Human Toxicity Excerpts (Complete) data for SODIUM IODIDE (10 total), please visit the HSDB record page. |
| F | 8 |
| Water hazard class (WGK) | 1 |
| TSCA inventory status | TSCA listed |
| RTECS number | WB6475000 |
| UN transport number | UN 3077 9 / PGIII |
| Customs code | 28276000 |
| Toxicity | MLD i.v. in rats: 1.3 g/kg, Loeser, Konwiser, J. Lab. Clin. Med. 15, 35 (1929) |
| Risk statements (R) | 36/38-36/37/38-50 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Hazard symbols | Xi,N |
| Safety statements (S) | 26-61 |
| Hazard class | 9Eye Irrit. 2 |
| Storage class | 13 - Non Combustible Solids |
| GHS hazard statements | H315-H319-H372-H400 |
| Limited quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
| REACH registrations | Active |
| GHS precautionary statements | P260-P264-P273-P302+P352-P305+P351+P338-P314 |
| Hazardous substances data | 7681-82-5(Hazardous Substances Data) |
Applications & Uses
Uses
Sodium iodide is widely used for halide exchange (Finkelstein reaction), for example in the conversion of an alkyl chloride, allyl chloride and arylmethyl chloride into their respective iodides, which are precursors for pharmaceutical and fine chemical products. They are used to ehnance the efficiency of the formation of Wittig adducts from less reactive chlorides and bromides. Appropriate prepartions find use as a nutrient supplement. Sodium iodide is used as the precursor to the control agent in ab initio emulsion polymerization. Sodium iodide finds use in the determination of dissolved oxygen in the modified Winkler method, synthesis of the fluorescent dye coppersensor-1 (CS1) for imaging labile copper pools in biological samples, and the cleavage of esters, lactones, carbamates and ethers in combination with chlorotrimethylsilane.
General Description
Sodium iodide is an inorganic salt. Mixture of chlorotrimethylsilane/sodium iodide in acetonitrile is a useful reagent for the cleavage of esters, lactones, carbamates and ethers.
Preparation & Synthesis
Preparation
Sodium iodide is prepared by adding hydriodic acid or an acidic iodide solution to a solution of sodium hydroxide or sodium carbonate, followed by evaporation and crystallization: NaOH + HI → NaI + H2OThe solution is filtered to remove any impurities prior to its evaporation and crystallization.