Basic information
- CAS
6817-41-0- Standard SMILES
COc1ccc(C[C@@H]2c3cc(Oc4cc(C[C@@H]5c6cc(O)c(OC)cc6CCN5C)ccc4O)c(OC)cc3CCN2C)cc1- InChIKey
AJPXZTKPPINUKN-FIRIVFDPSA-N- Molecular formula
- C37H42N2O6
- Average molar mass
- 610.7 g/mol
- Monoisotopic mass
- 610.30428706
Overview
Isoliensinine is a member of isoquinolines.
Names & identifiers
- Preferred name
- (+)-Isoliensinine
- IUPAC
- (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
- English name
- Isoliensinine
- Molecular formula
- C37H42N2O6
- Molecular weight
- 610.74
Names & synonyms
Isoliensinine6817-41-0(+)-Isoliensinine(1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-olDTXSID60218346(1R)-1-((4-hydroxy-3-(((1R)-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)oxy)phenyl)methyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-olRefChem:905467DTXCID801408371-((4-hydroxy-3-((6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenyl)methyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-olMFCD11042260CHEMBL502370SCHEMBL12807696
Show more names
(+)-IsoliensininIsoliensinine USP/EP/BPisoliensinine, lotusineIsoliensinine, 10 mM in DMSO(1R)-1-(4-hydroxy-3-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-m...(1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
Properties
Computed structural properties
- XLogP
- 6.4
- Topological polar surface area
- 83.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 9
- Heavy atoms
- 45
- Formal charge
- 0
- Complexity
- 917
Physicochemical properties
- Melting point
- 69 · 69-71℃
- Boiling point
- 723.1 · 723.1±60.0 °C(Predicted)
- Density
- 1.218 · 1.218
- storage temp.
- 2 · 2-8°C(protect from light)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- pka
- 9.28 · 9.28±0.45(Predicted)
- color
- White
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionTomita and his co-workers have obtained this bisisoquinoline alkaloid from the embryo of the seeds of Nelumbo nucifera Gaertn. The base has [α]29D + 49.3° (Me2CO) and - 43.3° (CHC13 ). The hydrochloride tetrahydrate forms colourless crystals, m.p. l85-6°C (dry); the perchlorate monohydrate has m.p. 200-3°C (dry); [α]22D - 70° (Me2CO) and the styphnate of the O,O-dimethyl ether, also crystalline, has m.p. l33-5°C; [α]27D - 81.5° (Me2CO). Three methoxyl, two hydroxyl and two methylimino groups are present.
Uses(+)-Isoliensinine is an alkaloid which displays activation of AMP-activated kinase and regulation of PPARγ receptors.
Suppliers100 total
北京华美互利生物化工010-56205725 · [email protected]
成都普瑞法科技开发有限公司+86-028-82633397 18982077548 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
成都曼思特生物科技有限公司18010516991 · [email protected]
南京普怡生物科技有限公司13814510036 · [email protected]
成都埃法生物科技有限公司028-028-85142057 19983342022 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
云南西力生物技术股份有限公司0871-65217109 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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