Basic information
- CAS
142852-51-5- Standard SMILES
O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2c(c1)NCCCC2.O=C(O)/C=C/C(=O)O- InChIKey
CWEHWZPCDBRUNO-WLHGVMLRSA-N- Molecular formula
- C29H36N2O5
- Average molar mass
- 492.6 g/mol
- Monoisotopic mass
- 492.26242225
Overview
Zanapezil fumarate is a polymer.
Names & identifiers
- Preferred name
- Zanapezil Fumarate
- IUPAC
- 3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one;(E)-but-2-enedioic acid
- English name
- but-2-enedioic acid
- Molecular formula
- C25H32N2O.C4H4O4
- Molecular weight
- 492.61
Names & synonyms
Zanapezil fumarateTAK-147142852-51-5263248-42-6TAK 147UNII-7Y1T8FKO1VZanapezil fumarate (JAN)ZANAPEZIL FUMARATE [JAN]3-(1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate1-Propanone, 3-(1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-,(E)-2-butenedioate (1:1)1-PROPANONE, 3-(1-(PHENYLMETHYL)-4-PIPERIDINYL)-1-(2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-8-YL)-, (2E)-2-BUTENEDIOATE (1:1)1-PROPANONE, 3-(1-(PHENYLMETHYL)-4-PIPERIDINYL)-1-(2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-8-YL)-, (E)-2-BUTENEDIOATE (1:1)
Show more names
but-2-enedioic acid{2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine, 1 g{2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine, 250 mg
RefChem:1958433-(1-Benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one monofumarate7Y1T8FKO1V3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)propan-1-one fumarate3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)propan-1-one;(E)-but-2-enedioic acid3-[1-(Phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone (2E)-2-butenedioate (1:1)263248-42-6 (fumarate)NCGC00183005-01
Properties
Computed structural properties
- Topological polar surface area
- 107 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 8
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 598
Physicochemical properties
- form
- Solid
- color
- White to off-white
- FDA UNII
- 7 Y1T8FKO1V · 7Y1T8FKO1V
Chemistry & industry
Applications
UsesZanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil can be used for the research of early stages of Alzheimer's disease (AD)[1][2].
Suppliers1 total
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
Additional notes
DefinitionChEBI: Zanapezil fumarate is a polymer.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…