Basic information
- CAS
27064-95-5- Standard SMILES
Cl.Cl.Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1- InChIKey
RXKMOPXNWTYEHI-RDRKJGRWSA-N- Molecular formula
- C26H28Cl2F2N2
- Average molar mass
- 477.4 g/mol
- Monoisotopic mass
- 476.1597606
Overview
Flunarizine hydrochloride is a diarylmethane.
Names & identifiers
- Preferred name
- Flunarizine Hydrochloride
- IUPAC
- 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;dihydrochloride
Names & synonyms
30484-77-6flunarizine hydrochlorideFlunarizine HClFlunarizine (as hydrochloride)FlurizinMigarid-10R 14950(E)-1-(Bis-(p-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochlorideHydrochloride, FlunarizineR-14950C11102TO53NSC-757807
Show more names
Dihydrochloride, FlunarizineR 14,950DTXSID80184554Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-RefChem:599353DTXCID20107045250-216-6Flunarizine dihydrochloride
Database identifiers
- CAS
27064-95-5、30484-77-6- PubChem CID
- 5282407
- DTXSID
DTXSID80184554- ChEMBL
CHEMBL539027、CHEMBL552659- ChEBI
CHEBI:31621- UNII
- C11102TO53
- EC Number
- 248-203-5、250-216-6
Properties
Computed structural properties
- Topological polar surface area
- 6.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 487
Experimental & physicochemical properties
Collision Cross Section210.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1% (1 of 99) of reports.
Warning
H302 (99%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 99 reports by companies from 6 notifications to the ECHA C&L Inventory.
Hazard information
Other Safety InformationIMAP assessments - Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (99%)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used to prevent SEIZURES or reduce their severity.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Drugs used to cause dilation of the blood vessels.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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