11-Deoxyprostaglandin F1alpha
Basic information
- CAS
37785-98-1- Standard SMILES
CCCCC[C@H](O)/C=C/[C@H]1CC[C@H](O)[C@@H]1CCCCCCC(=O)O- InChIKey
HYBPXYQCXNOTFK-DUSCRHDRSA-N- Molecular formula
- C20H36O4
- Average molar mass
- 340.5 g/mol
- Monoisotopic mass
- 340.26135963
Overview
11-Deoxy-PGF1alpha is a prostanoid.
Names & identifiers
- Preferred name
- 11-Deoxyprostaglandin F1alpha
- IUPAC
- 7-[(1R,2S,5R)-2-hydroxy-5-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid
- English name
- 11-Deoxy prostaglandin f1alpha
- Molecular formula
- C20H36O4
- Molecular weight
- 340.5
Names & synonyms
37785-98-111-Deoxyprostaglandin F1alpha11-Deoxy-pgf1alphaDTXSID101347757RefChem:907980DTXCID501776493prost-13-en-1-oic acid, 9,15-dihydroxy-, (9 alpha,13E,15S)-11-deoxy Prostaglandin F1alpha11-deoxy-PGF1a7-[(1R,2S,5R)-2-hydroxy-5-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid11-deoxy-Prostaglandin F1a11-deoxy Prostaglandin F1|A
Show more names
11-deoxy Prostaglandin F1αHYBPXYQCXNOTFK-DUSCRHDRSA-N9ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID
9S,15S-dihydroxy-13E-prostaenoic acidProst-13-en-1-oic acid, 9,15-dihydroxy-, (9alpha,13E,15S)-11-deoxy Prostaglandin F1??orb1693455SCHEMBL3366567CHEBI:165302HMS3648L1711-DEOXY PROSTAGLANDIN F1
Database identifiers
- CAS
37785-98-1- PubChem CID
- 5283069
- DTXSID
DTXSID101347757
Properties
Computed structural properties
- XLogP
- 4.4
- Topological polar surface area
- 77.8 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 13
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 367
Experimental & physicochemical properties
LipidsFatty Acyls [FA] -> Eicosanoids [FA03] -> Prostaglandins [FA0301]
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 50 mg/ml · DMF: >50 mg/ml (from PGF1a); DMSO: >50 mg/ml (from PGF1a); Ethanol: >75 mg/ml (from PGF1a); PBS pH 7.2: >2 mg/ml (from PGF1a)
- form
- A crystalline solid
Chemistry & industry
Applications
Description11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.
Uses11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor[1][2].
Additional notes
DefinitionChEBI: 11-Deoxy-PGF1alpha is a prostanoid.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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