Basic information
- CAS
177020-26-7- Standard SMILES
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C/C=C\CCCC(=O)O)[C@H](O)C[C@H]1O- InChIKey
PXGPLTODNUVGFL-HMALSPAFSA-N- Molecular formula
- C20H34O5
- Average molar mass
- 354.5 g/mol
- Monoisotopic mass
- 354.24062418
Names & identifiers
- Preferred name
- 8-iso-PGF2beta
- IUPAC
- (Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
- English name
- 8-ISO prostaglandin F2BeTa
- Molecular formula
- C20H34O5
- Molecular weight
- 354.48
Names & synonyms
8-iso-PGF2beta177020-26-7(Z)-7-[(1S,2R,3R,5R)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid8-iso Prostaglandin F2|A9R,11R,15S-trihydroxy-5Z,13E-prostadienoic acid-cyclo[8S,12R]8-isoprostaglandin PGF2beta8-iso PGF2beta8-iso-PGF2b8-iso-PGF(2beta)8-Isoprostaglandinf2beta8-isoprostaglandin PGF2b8-iso Prostaglandin F2??
Show more names
8-ISO-9BETA-PGF2ALPHA8-iso Prostaglandin F2β8-ISO prostaglandin F2BeTa9alpha,11alpha,15S-trihydroxy-(8beta)-prost-5Z,13E-dien-1-oic-acid9BETA,11ALPHA,15S-TRIHYDROXY-(8BETA)-PROSTA-5Z,13E-DIEN-1-OIC ACIDProsta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9β,11α,13E,15S)-
orb1693105PXGPLTODNUVGFL-HMALSPAFSA-NDTXSID401160411HMS3648B10LMFA03110006MFCD00216066AKOS040755655PD021317
Database identifiers
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 98 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 12
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 432
Experimental & physicochemical properties
Physical DescriptionSolid
Physicochemical properties
- Boiling point
- 531 · 531.0±50.0 °C(Predicted)
- Density
- 1.153 · 1.153±0.06 g/cm3(Predicted)
- solubility
- 10 mM · 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)
- pka
- 4.76 · 4.76±0.10(Predicted)
- Symbol(GHS)
- 2 · GHS02,GHS07,GHS08
- Signal word
- Danger
Safety & regulation
Safety data
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS07,GHS08
Chemistry & industry
Pharmacology
Cellular LocationsExtracellular；Membrane
Applications
Description8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α
Uses8-iso Prostaglandin F2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress[1].
Suppliers6 total
上海一研生物科技有限公司021-69985186 13611928337 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
1 records
Compound notes
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