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Basic information
- CAS
27912-14-7- Standard SMILES
CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O.Cl- InChIKey
DNTDOBSIBZKFCP-YDALLXLXSA-N- Molecular formula
- C17H26ClNO3
- Average molar mass
- 327.8 g/mol
- Monoisotopic mass
- 327.16012137
Overview
Levobunolol hydrochloride is a hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective beta-adrenergic antagonist used for treatment of glaucoma. It has a role as a beta-adrenergic antagonist and an antiglaucoma drug. It contains a levobunolol(1+).
Names & identifiers
- Preferred name
- Levobunolol Hydrochloride
- IUPAC
- 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride
Names & synonyms
levobunolol hydrochloride27912-14-7Levobunolol HClAkbetaBetaganDTXSID6020777W 7000ANSC-759158W-7000AO90S49LDHHDTXCID20777CHEBI:6439
Show more names
(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochlorideRefChem:55472W7000A248-725-3Levobunolol (hydrochloride)Levobunolol.HClGotensin(-) -Levobunolol hydrochloride
Database identifiers
- CAS
27912-14-7- PubChem CID
- 5284409
- DTXSID
DTXSID6020777- ChEMBL
CHEMBL1201177- ChEBI
CHEBI:6439- UNII
- O90S49LDHH
- EC Number
- 248-725-3
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 58.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 350
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.
Warning
H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 3 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (97.9%)
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
LEVOBUNOLOL HYDROCHLORIDE
beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Related reactions
1 records
Compound notes
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