Basic information
- CAS
121961-22-6- Standard SMILES
N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CC[C@H]12)c1ccccc1.O- InChIKey
GPYKKBAAPVOCIW-HSASPSRMSA-N- Molecular formula
- C16H18ClN3O5
- Average molar mass
- 367.78 g/mol
- Monoisotopic mass
- 367.0934984
Names & identifiers
- Preferred name
- Loracarbef monohydrate
- IUPAC
- (6R,7S)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate
- English name
- LORACARBEF (200 MG)
- Molecular formula
- C16H16ClN3O4.H2O
- Molecular weight
- 367.787
Names & synonyms
Loracarbef monohydrate121961-22-6DTXSID5048718DTXCID2028644RefChem:154088Loracarbef hydrateLoracarbef (hydrate)LorafemCarbacLorabid (TN)LY 163892 monohydrateLY 163892 (hydrate)
Show more names
kt3777ly163892CarbacefaclorLORACARBEF (200 MG)LORACARBEF USP/EP/BPLORACARBEF (200 MG) USP/EP/BPLoracarbef (LY-163892) monohydratemonohydrate,(6r-(6-alpha,7-beta(r*)))-chloro-8-oxo7-((aminophenylacetyl)amino)-3-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci
(6R,7S)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrateLoracarbef (USP)(6R,7S)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, monohydrate(6R,7S)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrateUNII-3X11EVM5SUNCGC00185746-01(6R,7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrateLORACARBEF [JAN]
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 114 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 600
Physicochemical properties
- Melting point
- 205 · 205-215° (dec) (Matsukuma)
- alpha
- 21 · D21 +34.0° (c = 0.35 in water)
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly)
- form
- Solid
- color
- White to Off-White
- FDA UNII
- 3 X11EVM5SU · 3X11EVM5SU
- HS Code
- 2941906000 · 2941906000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory Information1-Azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-chloro-8-oxo-, monohydrate, (6R,7S)-: Does not have an individual approval but may be used under an appropriate group standard
Safety data
- hs_code
- 2941906000
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Applications
DescriptionLoracarbef is a new orally active, broad-spectrum cephalosporin suitable for twice a day dosing. It is approved for use in both adults and children for the treatment of upper and lower respiratory tract infections, urinary tract and skin infections.
UsesLORACARBEF's antibacterial activity is similar to that of cefaclor and cefuroxime aspirin, and it is used for pneumonia, pharyngitis, chronic bronchitis, secondary bacterial infections of mild to moderate acute bronchitis, tonsillitis, etc. caused by susceptible bacteria.
Upstream & downstream products
Upstream raw materials
Suppliers4 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Related reactions
0 records
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Compound notes
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