Basic information
- CAS
1247-42-3- Standard SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO- InChIKey
PIDANAQULIKBQS-RNUIGHNZSA-N- Molecular formula
- C22H28O5
- Average molar mass
- 372.5 g/mol
- Monoisotopic mass
- 372.19367399
Overview
Meprednisone is a 21-hydroxy steroid.
Names & identifiers
- Preferred name
- Meprednisone
- IUPAC
- (8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
- English name
- Meprednisone
- Molecular formula
- C22H28O5
- Molecular weight
- 372.45
Names & synonyms
meprednisone1247-42-3BetaparMeprednisonaSch 4358MeprednisonumDTXSID8023260NSC-527579SCH-435867U96J8P35Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16beta)-DTXCID503260
Show more names
Methylprednisone16-BETA-METHYLPREDNISONEbetalonebetapredNSC 527579bitanisonedeltisonab
16-methylprednisoneNSC527579RefChem:57253H02AB15(1S,2R,10S,11S,13S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo(8.7.0.02,?.011,1?)heptadeca-3,6-diene-5,17-dione214-996-1Betapar(Meprednisone)Betanisona
Database identifiers
- CAS
1247-42-3- PubChem CID
- 5284587
- DTXSID
DTXSID8023260- ChEMBL
CHEMBL1201148- ChEBI
CHEBI:135573- UNII
Properties
Computed structural properties
- XLogP
- 1.9
- Topological polar surface area
- 91.7 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 795
Experimental & physicochemical properties
Drugs
Pharmaceuticals -> Steroids
Pharmaceuticals -> Listed in ZINC15
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Melting point
- 204 · 204-2060C
- alpha
- 200 ° · D +200° (dioxane)
- Boiling point
- 574.4 · 574.4±50.0 °C(Predicted)
- Density
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.38 · 12.38±0.70(Predicted)
- form
- Solid
- color
- White
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
Danger
H360Df (50%): May damage the unborn child; Suspected of damaging fertility [Danger Reproductive toxicity]
P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesRepr. 1A (50%)
Safety data
- hs_code
- 2937290000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280-P301+P312-P302+P352-P305+P351+P338
Chemistry & industry
Pharmacology
ATC Code
H - Systemic hormonal preparations, excl. sex hormones and insulins
QH - Systemic hormonal preparations, excl. sex hormones and insulin
Applications
UsesCorticosteroid.
UsesBetapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. [1]The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to a
Upstream & downstream products
Upstream raw materials
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
Hebei shuoxi biotechnology co. LTD+8613081092107
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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