Basic information
- CAS
61-56-3- Standard SMILES
NS(=O)(=O)c1ccc(N2CCCCS2(=O)=O)cc1- InChIKey
HMHVCUVYZFYAJI-UHFFFAOYSA-N- Molecular formula
- C10H14N2O4S2
- Average molar mass
- 290.4 g/mol
- Monoisotopic mass
- 290.03949928
Overview
Sultiame is an organic molecular entity.
Names & identifiers
- Preferred name
- Sulthiame
- IUPAC
- 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
- English name
- sultiame
- Molecular formula
- C10H14N2O4S2
- Molecular weight
- 290.36
Names & synonyms
sultiameSULTHIAME61-56-3OspolotTrolonesultiamConadilSultiamumRiker 594SultiamoDTXSID4023626p-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide, S,S-dioxide
Show more names
A 168ElisalCanadilSulthiaMContravul
Benzenesulfonamide, 4-(tetrahydro-2H-1,2-thiazin-2-yl)-, S,S-dioxideRIKER-594I00Q766CZ2DTXCID503626RefChem:186763N03AX034-(1,1-dioxo-1??,2-thiazinan-2-yl)benzene-1-sulfonamide4-(3,4,5,6-Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide S,S-dioxide
Database identifiers
- CAS
61-56-3- PubChem CID
- 5356
- DTXSID
DTXSID4023626- ChEMBL
CHEMBL328560- ChEBI
CHEBI:32171- UNII
- I00Q766CZ2
- EC Number
- 200-511-0
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 114 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 2
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 481
Experimental & physicochemical properties
Drugs
Pharmaceuticals -> Listed in ZINC15
Pharmaceuticals
Pharmaceuticals -> Antiepileptics
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
Physicochemical properties
- Melting point
- 180 · 180-182°
- Boiling point
- 520.2 · 520.2±60.0 °C(Predicted)
- Density
- 1.472 · 1.472±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- DMSO: slightly; Methanol: slightly
- form
- A solid
- pka
- 9.9 · 9.90±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)
- InChIKey
- HMHVCUVYZFYAJI-UHFFFAOYSA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
Warning
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationBenzenesulfonamide, 4-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (50%)
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H315-H319
- Hazard Classifications
- Acute Tox. 4 Oral
- Precautionary statements
- P264-P280-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
Mechanism of ActionSulthiame is an indiscriminate inhibitor of all the catalytically active isoforms of mammalian carbonic anhydrase.
MeSH Pharmacological ClassificationDrugs used to prevent SEIZURES or reduce their severity.
Uses & manufacturing
UsesUse (kg; approx.) in Germany (2009): >75
Applications
UsesSulthiame is a benzenesulfonamide derivative. Sulthiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.
UsesSultiame is a benzenesulfonamide derivative. Sultiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.
Suppliers46 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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