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Sultopride

HCID 5357
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
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Basic information

CAS
53583-79-2
Standard SMILES
CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC
InChIKey
UNRHXEPDKXPRTM-UHFFFAOYSA-N
Molecular formula
C17H26N2O4S
Average molar mass
354.5 g/mol
Monoisotopic mass
354.16132849

Overview

Sultopride is a member of salicylamides.

Names & identifiers

Preferred name
Sultopride
IUPAC
N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
English name
Sultopride
Molecular formula
C17H26N2O4S
Molecular weight
354.468

Names & synonyms

Sultopride53583-79-2SultopridumSultopridaAA0G3TW31WN-((1-Ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamideBenzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-DTXSID9023627N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamideN-((1-ethylpyrrolidin-2-yl)methyl)-5-ethylsulfonyl-2-methoxy-benzamide(+-)-SultoprideRefChem:890031
Show more names
N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamideBenzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-N-[(1-Ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-(methyloxy)benzamide4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamidBenzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy- (9CI)
DTXCID903627N05AL02N-(Ethyl-1-pyrrolidinyl-2-methyl)methoxy-2-ethylsulfonyl-5-benzamide258-641-9BarnetilTopralSultopridum [INN-Latin]LIN 1418

Properties

Computed structural properties

XLogP
1.6
Topological polar surface area
84.1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
5
Rotatable bonds
7
Heavy atoms
24
Formal charge
0
Complexity
517

Experimental & physicochemical properties

LogP2.05
Human DrugsBreast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Dopamine Antagonists

Physicochemical properties

Melting point
181 · 181-182 °C
Boiling point
530 · 530.0±50.0 °C(Predicted)
Density
1.1814 · 1.1814 (rough estimate)
refractive index
1.693 · 1.6930 (estimate)
storage temp.
-20 °C · Store at -20°C
solubility
Soluble in DMSO
pka
13.99 · 13.99±0.46(Predicted)
FDA UNII
0 G3TW31W · AA0G3TW31W
ATC code
5 AL02 · N05AL02
Symbol(GHS)
7 · GHS07
Signal word
Warning
Hazard statements

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxicology

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

Safety data

Signal word
Warning
Symbol(GHS)
GHS07
Hazard statements
H302-H315-H319-H335
Precautionary statements
P261-P305+P351+P338

Chemistry & industry

Pharmacology

ATC Code · 2 items

N - Nervous system

QN - Nervous system

MeSH Pharmacological Classification · 3 items

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

Upstream & downstream products

Upstream raw materials

Phosphorus trichloride2-Methoxy-5-(ethylsulfonyl)benzoic acid

Suppliers21 total

沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]

Related reactions

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes

Database identifiers

CAS
53583-79-2
PubChem CID
5357
DTXSID
DTXSID9023627
ChEMBL
CHEMBL277945
ChEBI
CHEBI:9356
UNII
AA0G3TW31W
EC Number
258-641-9
Nikkaji
J10.063C
302 · H302-H315-H319-H335
Precautionary statements
261 · P261-P305+P351+P338
湖北金梭生物科技有限公司
00123456789 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
天成化工(江苏)有限公司0512-66387919 18662433356 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
普善实业(陕西)有限公司029-81310890 18165209495 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
BOC Sciences[email protected]
Shaanxi Didu New Materials Co. Ltd+86-86-17392712779 +86-13289823923 · [email protected]
成都圣美凯生物科技有限公司028-85157043 15882256948 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
SUZHOU SENFEIDA CHEMICAL CO.,LTD+86-0512-83500002 +86-15195660023 · [email protected]
上海齐奥化工科技有限公司021-58892003 · [email protected]
上海传芊化工科技中心15869524721 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418671 +86-189 4982 3763 · [email protected]

Additional notes

DefinitionChEBI: Sultopride is a member of salicylamides.