Basic information
- CAS
74196-92-2- Standard SMILES
CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@H]21- InChIKey
FTSUPYGMFAPCFZ-ZWNOBZJWSA-N- Molecular formula
- C13H21N3
- Average molar mass
- 219.33 g/mol
- Monoisotopic mass
- 219.17354768
Overview
Quinpirole is a pyrazoloquinoline that is (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist. It has a role as a dopamine agonist.
Names & identifiers
- Preferred name
- Quinpirole
- IUPAC
- (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[5,4-g]quinoline
- English name
- Quinpirole
- Molecular formula
- C13H21N3
- Molecular weight
- 219.33
Names & synonyms
QUINPIROLE80373-22-4QuinpirolQuinpirolumCHEBI:754011H-Pyrazolo(3,4-g)quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, (4aR-trans)-20OP60125T(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo(3,4-g)quinolineDTXSID9048229(4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrido[2,3-f]indazole(4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrido(2,3-f)indazoleRefChem:930496
Show more names
LY-156258(4aR,8aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline1H-Pyrazolo[3,4-g]quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, (4aR,8aR)-
DTXCID4028204Quinpirole [INN](4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline(4aR,8aR)-5-Propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinolineCHEMBL24077385760-74-3Quinpirol [Spanish]Quinpirolum [Latin]
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 2.3
- Topological polar surface area
- 31.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 243
Physicochemical properties
- Boiling point
- 383.9 · 383.9±30.0 °C(Predicted)
- Density
- 1.07 · 1.070±0.06 g/cm3(Predicted)
- pka
- 15.4 · 15.40±0.20(Predicted)
- FDA UNII
- 20 OP60125T · 20OP60125T
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationDrugs that bind to and activate dopamine receptors.
Applications
UsesQuinpirole (LY 171555) is a dopamine D2/D3 receptor agonist with activity in reducing hypothalamic norepinephrine concentrations. The effects of Quinpirole are not produced by the selective D1 agonist SKF 38393 or the dextrorotatory isomer of Quinpirole, which lacks D2 agonist activity. By activating D2 receptors, Quinpirole leads to a decrease in dopamine metabolites, a decrease in hypothalamic norepinephrine concentrations, and a possible increase in MHPG sulfate by enhancing norepinephrine release[1].
Suppliers2 total
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Additional notes
DefinitionChEBI: A pyrazoloquinoline that is (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.
Related reactions
0 records
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Compound notes
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