Basic information
- CAS
1345980-40-6- Standard SMILES
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccccc1OCCOc1cc(-c2c3ccc(=O)cc-3oc3cc(OCOC(C)=O)ccc23)ccc1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O- InChIKey
BKYHTWFRZPRHNM-UHFFFAOYSA-N- Molecular formula
- C50H50N2O23
- Average molar mass
- 1,046.9 g/mol
- Monoisotopic mass
- 1,046.28043585
Overview
Fluo-8 AM is a fluorescent calcium indicator commonly used in cell biology and molecular biology research to measure intracellular calcium levels.
Names & identifiers
- Preferred name
- Fluo-8 AM
- IUPAC
- acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-4-[3-(acetyloxymethoxy)-6-oxoxanthen-9-yl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
- English name
- N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[2-[2-[5-[6-[(acetyloxy)methoxy]-3-oxo-3H-xanthen-9-yl]-2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenoxy]ethoxy]phenyl]glycine (acetyloxy)methyl ester
- Molecular formula
- C50H50N2O23
- Molecular weight
- 1046.93
Names & synonyms
Fluo-8 AM1345980-40-6FLUO-8 (AM)acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-4-[3-(acetyloxymethoxy)-6-oxoxanthen-9-yl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetateGlycine, N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[2-[5-[6-[(acetyloxy)methoxy]-3-oxo-3H-xanthen-9-yl]-2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenoxy]ethoxy]phenyl]-, (acetyloxy)methyl esterFluo-8, AMSCHEMBL828166SCHEMBL29418265SCHEMBL30310160CHEBI:233002C50H50N2O23MFCD27977558
Show more names
Fluo-2 AMFluo-8, AM esterFluo-8 AM Calcium Probe(Green)Fluo-8 AM Calcium Fluorescent Probes (Green)Fluo-8 AM, green fluorescent calcium binding dye1H-Benz[e]indolium, 2-[7-[3-(5-carboxypentyl)-1,3-dihydro-1,1-dimethyl-6,8-disulfo-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-3-ethyl-1,1-dimethyl-6,8-disulfo-, inner salt (ACI)
Properties
Computed structural properties
- XLogP
- 4.7
- Topological polar surface area
- 297 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 25
- Rotatable bonds
- 36
- Heavy atoms
- 75
- Formal charge
- 0
- Complexity
- 2,090
Physicochemical properties
- Boiling point
- 1051 · 1051.0±65.0 °C(Predicted)
- Density
- 1.45 · 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- waxy solid
- pka
- 1.56 · 1.56±0.50(Predicted)
- color
- Dark
- Stability
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H315
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/38
- Safety Statements
- 26 · 26
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- risk_code
- 36/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26
- Hazard statements
- H319-H315
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Applications
DescriptionFLUO-8 (AM) is a cell-permeable acetoxymethyl (AM) ester derivative of Fluo-8. Approximately twice as bright as Fluo-4. Absorbance 452 nm (26,000); Emission 515 nm (after AM hydrolysis; dissolved in 10 mM EGTA, 100 mM KCl, 10 mM MOPS, pH 7.2)
UsesFLUO-8 (AM) is a green fluorescent calcium binding dye. It is a tool in making the determination of drug resistance in cells.
Suppliers19 total
武汉恩玑生命科技有限公司027-87002838 13212728378 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
上海梅凯科技有限公司021-68689288 15300790979 · [email protected]
上海沣植生物科技中心18221507856 · [email protected]
山东康赛德生物科技有限公司18615616891 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
西安百萤生物科技有限公司029-029-68064558 18502920169 · [email protected]
上海萄普生物医药技术有限公司15900573766 18018507602 · [email protected]
风咏生物（AbMole）021-10000000 13000000000 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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