Basic information
- CAS
72141-57-2- Standard SMILES
O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1- InChIKey
SYJKIRZBDWNJSB-UHFFFAOYSA-N- Molecular formula
- C27H22F4N4O3S
- Average molar mass
- 558.5 g/mol
- Monoisotopic mass
- 558.1348744
Names & identifiers
- Preferred name
- Losulazine
- IUPAC
- [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone
- English name
- Losulazine
- Molecular formula
- C27H22F4N4O3S
- Molecular weight
- 558.55
Names & synonyms
Losulazine72141-57-2LosulazinaLosulazine [INN]LosulazinumLosulazinum [Latin]Losulazina [Spanish]UNII-O2978JQ9B7BRN 6257178O2978JQ9B71-((4-Fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)piperazineLosulazinum (Latin)
Show more names
1-[(4-Fluorophenyl)sulfonyl]-4-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]benzoyl]piperazineMethanone, [4-[(4-fluorophenyl)sulfonyl]-1-piperazinyl][4-[[7-(trifluoromethyl)-4-quinolinyl]amino]phenyl]-
Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)-1-((P-FLUOROPHENYL)SULFONYL)-4-(P-((7-(TRIFLUOROMETHYL)-4-QUINOLYL)AMINO)BENZOYL)PIPERAZINE1-[(4-fluorophenyl)sulfonyl]-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazineRefChem:154119[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanoneCHEMBL287419orb1819161SCHEMBL1817022
Database identifiers
- CAS
72141-57-2- PubChem CID
- 54750
- DTXSID
DTXSID20868088- ChEMBL
CHEMBL287419- UNII
- O2978JQ9B7
- Nikkaji
- J23.274B
Properties
Computed structural properties
- XLogP
- 4.8
- Topological polar surface area
- 91 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 5
- Heavy atoms
- 39
- Formal charge
- 0
- Complexity
- 938
Physicochemical properties
- FDA UNII
- 2978 JQ9B7 · O2978JQ9B7
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
Safety & regulation
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
UsesLosulazine is used in the preparation of 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics.
Suppliers6 total
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
United Life Science020-82099279 18988941402 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
Related reactions
2 records
Compound notes
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