GW296115X

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Basic information

CAS: 118458-58-5
Standard SMILES: COc1ccc2[nH]c3c4[nH]c5ccc(OC)cc5c4c4c(c3c2c1)C(=O)NC4=O
InChIKey: LGTURXDQKJRHSF-UHFFFAOYSA-N
Molecular formula: C22H15N3O4
Average molar mass: 385.4 g/mol
Monoisotopic mass: 385.10625597

Overview

GW296115X is an indolocarbazole compound having methoxy groups at positions 3 and 9 and an additional fused pyrrolidine-2,5-dione ring. It is an inhibitor of BRSK2 kinase, PDGF-dependent receptor autophosphorylation and cell proliferation. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is an aromatic ether, an organic heterohexacyclic compound and an indolocarbazole.

Names & identifiers

Preferred name: GW296115X
IUPAC: 7,19-dimethoxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
English name: 12,13-Dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Molecular formula: C22H15N3O4
Molecular weight: 385.37

Names & synonyms

118458-58-512,13-Dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dioneGW296115X3,9-dimethoxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione3744WCHEBI:1431213744-WGW29611512,13-dihydro-3,9-dimethoxy-5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione3,9-dimethoxy-12,13-dihydro-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dioneRefChem:347059CHEMBL1956068

Show more names

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-3,9-dimethoxy-

7,19-dimethoxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dioneorb3236621SCHEMBL8120713SCHEMBL31281911DTXSID60420508GLXC-03297EX-A9390BDBM50365215

Database identifiers

CAS

Properties

Computed structural properties

XLogP: 3.6
Topological polar surface area: 96.2 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 4
Rotatable bonds: 2
Heavy atoms: 29
Formal charge: 0
Complexity: 658

Chemistry & industry

Additional notes · 1 item

DefinitionChEBI: GW296115X is an indolocarbazole compound having methoxy groups at positions 3 and 9 and an additional fused pyrrolidine-2,5-dione ring. It is an inhibitor of BRSK2 kinase, PDGF-dependent receptor autophosphorylation and cell proliferation. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is an organic heterohexacyclic compound, an indolocarbazole and an aromatic ether.

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