Enkephalin-met, ala(2)-
Basic information
- CAS
61370-87-4- Standard SMILES
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O- InChIKey
MHNSNPIYASDSCR-SZOBAZRNSA-N- Molecular formula
- C28H37N5O7S
- Average molar mass
- 587.7 g/mol
- Monoisotopic mass
- 587.24136971
Overview
synthetic analog of methionine enkephalin
Names & identifiers
- Preferred name
- Enkephalin-met, ala(2)-
- IUPAC
- (2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
- English name
- Tyr-D-Ala-Gly-Phe-Met
- Molecular formula
- C28H37N5O7S
- Molecular weight
- 587.69
Names & synonyms
enkephalin-Met, Ala(2)-61370-87-4Dalmee2-Ala-met-enkephalinDAMETMet-enkephalin, ala(2)-Enkephalin-met, alanine(2)-Methionine-enkephalin, ala(2)-L-Methionine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-RefChem:136904[D-Ala2]-Met-Enkephalin(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Show more names
ala(2)-enkephalin-meTyr-D-Ala-Gly-Phe-Met(D-ALA2) MET-ENKEPHALINL-TYR-D-ALA-GLY-PHE-METa,a-D-Trehaloseanhydrous[D-ALA2,MET5]-ENKEPHALIN
L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-methionine[DAla2] Met-Enkephalinorb1986086CHEMBL3250190SCHEMBL29390218DTXSID50976908HY-P2626AKOS027383016
Properties
Computed structural properties
- XLogP
- -1.7
- Topological polar surface area
- 225 Ų
- Hydrogen bond donors
- 7
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 16
- Heavy atoms
- 41
- Formal charge
- 0
- Complexity
- 878
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationCompounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Applications
DescriptionEnkephalin-met, ala(2)- is a synthetic analog of methionine enkephalin.
Uses[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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