Glutamyl-histidyl-isoleucyl-prolyl-alanine
Completing data — refresh the page later to see the latest
Basic information
- CAS
137235-80-4- Standard SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O- InChIKey
VWJLJHZPMZGDDV-HOCDWTQPSA-N- Molecular formula
- C25H39N7O8
- Average molar mass
- 565.6 g/mol
- Monoisotopic mass
- 565.28601121
Overview
binds fibrinogen & inhbits platelet aggregation & adhesion to fibrinogen & vitronectin
Names & identifiers
- Preferred name
- Glutamyl-histidyl-isoleucyl-prolyl-alanine
- IUPAC
- (4S)-4-amino-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(1S)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
- English name
- FIBRINOGEN-BINDING PEPTIDE
- Molecular formula
- C25H39N7O8
- Molecular weight
- 565.62
Names & synonyms
137235-80-4Glu-his-ile-pro-alaGlutamyl-histidyl-isoleucyl-prolyl-alanineDTXSID80160116RefChem:143686DTXCID5082607Fibrinogen-Binding Peptide(4S)-4-amino-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(1S)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidorb321061orb1983830CHEMBL1409520SCHEMBL29613679
Show more names
EHIPAH-GLU-HIS-ILE-PRO-ALA-OHFibrinogen-Binding Peptide (3)Fibrinogen-Binding Peptide butylL-α-Glutamyl-L-histidyl-L-isoleucyl-L-prolyl-L-alanineL-Alanine, L-α-glutamyl-L-histidyl-L-isoleucyl-L-prolyl-
SCHEMBL29973360HY-P1741TP1736NCGC00167251-01DA-63437MS-30246CS-0095106F3204
Properties
Computed structural propertiesFilling in
- XLogP
- -3.1
- Topological polar surface area
- 237 Ų
- Hydrogen bond donors
- 7
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 15
- Heavy atoms
- 40
- Formal charge
- 0
- Complexity
- 948
Physicochemical properties
- Boiling point
- 1067.8 · 1067.8±65.0 °C(Predicted)
- Density
- 1.343 · 1.343±0.06 g/cm3(Predicted)
- storage temp.
- -15 °C · -15°C
- pka
- 3.7 · 3.70±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Glu-His-Ile-Pro-Ala
Chemistry & industry
Applications
UsesFibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin[1].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…