9H-Pyrido(3,4-b)indole, 1-methyl-, hydrochloride (1:1)
Basic information
- CAS
21655-84-5- Standard SMILES
Cc1nccc2c1[nH]c1ccccc12.Cl- InChIKey
COVNOIRYDKHLJD-UHFFFAOYSA-N- Molecular formula
- C12H11ClN2
- Average molar mass
- 218.68 g/mol
- Monoisotopic mass
- 218.0610761
Names & identifiers
- Preferred name
- 9H-Pyrido(3,4-b)indole, 1-methyl-, hydrochloride (1:1)
- IUPAC
- 1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
- English name
- Harman hydrochloride
- Molecular formula
- C12H11ClN2
- Molecular weight
- 218.68
Names & synonyms
Harman hydrochloride21655-84-5TC01Z184R9DTXSID201760399H-Pyrido(3,4-b)indole, 1-methyl-, hydrochloride (1:1)RefChem:914806DTXCID2098530244-507-7Harmane hydrochloride1-methyl-9H-pyrido[3,4-b]indole hydrochloridePrestwick_253ARIBINE HYDROCHLORIDE
Show more names
METHYL-4-CARBOLINE HYDROCHLORIDEharman hydrochloride monohydrateHarman hydrochloride, 10 mM in DMSO1-Methyl-9H-pyrido[3,4-b]indole.HCl1-methyl-9H-beta-carboline hydrochloride1-methyl-9H-pyrido[3,4-b]indol hydrochloride
LOTURINE HYDROCHLORIDEPASSIFLORIN HYDROCHLORIDE1-Methyl-9H-pyrido(3,4-b)indole hydrochloride1-methyl-9H-pyrido[3,4-b]indole;hydrochloride9H-Pyrido(3,4-b)indole, 1-methyl-, monohydrochloride3-METHYL-4-CARBOLINE HYDROCHLORIDECCRIS 7888Harmane HCl
Database identifiers
- CAS
21655-84-5- PubChem CID
- 5487918
- DTXSID
DTXSID20176039- ChEMBL
CHEMBL510348- UNII
- TC01Z184R9
- EC Number
- 244-507-7
Properties
Computed structural properties
- Topological polar surface area
- 28.7 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 15
- Formal charge
- 0
- Complexity
- 216
Physicochemical properties
- Melting point
- 290 °C · 290°C
- storage temp.
- Sealed in dry,Room Temperature
- FDA UNII
- 1 Z184R9 · TC01Z184R9
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.
Applications
UsesHarmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF)[1][2][3][4][5][6].
Related reactions
0 records
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Compound notes
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