Uroguanylin

HCID 5488765

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Basic information

CAS: 152175-68-3
Standard SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)C(C)C
InChIKey: SJMPVWVIVWEWJK-AXEIBBKLSA-N
Molecular formula: C61H101N17O25S4
Average molar mass: 1,600.8 g/mol
Monoisotopic mass: 1,599.6037365

Overview

amino acid sequence given in first source; stimulates intestinal guanylate cyclase; GenBank Z83746 (pig)

Names & identifiers

Preferred name: Uroguanylin
IUPAC: (4S)-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S,3R)-1-[[2-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-5-oxopentanoic acid
English name: uroguanylin
Molecular formula: C61H101N17O25S4
Molecular weight: 1600.81

Names & synonyms

Uroguanylin152175-68-3EWY1XP1HMZDTXSID10164965Guanylin (rat reduced), 1-L-glutamine-2-L-glutamic acid-3-L-aspartic acid-6-L-leucine-8-L-isoleucine-9-L-asparagine-10-L-valine-RefChem:193318DTXCID4087456UNII-EWY1XP1HMZSCHEMBL6442033EX-A8381CQ7900863L-Cysteine, L-glutaminyl-L-|A-glutamyl-L-|A-aspartyl-L-cysteinyl-L-|A-glutamyl-L-leucyl-L-cysteinyl-L-isoleucyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-

Show more names

L-Cysteine, L-glutaminyl-L-α-glutamyl-L-α-aspartyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-isoleucyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-

L-Glutaminyl-L-alpha-glutamyl-L-alpha-aspartyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-isoleucyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteine

Database identifiers

CAS: 152175-68-3
PubChem CID: 5488765
DTXSID: DTXSID10164965

Properties

Computed structural properties

XLogP: -8.8
Topological polar surface area: 693 Å²
Hydrogen bond donors: 26
Hydrogen bond acceptors: 30
Rotatable bonds: 52
Heavy atoms: 107
Formal charge: 0
Complexity: 3,190

Physicochemical properties

FDA UNII: 1 XP1HMZ · EWY1XP1HMZ

Chemistry & industry

Pharmacology

MeSH Pharmacological ClassificationCompunds that bind to and activate GUANYLYL CYCLASE-C RECEPTORS.

Suppliers4 total

康明永瑞生物科技（苏州）有限公司17751201929; 17751201929 · [email protected]

上海源叶生物科技有限公司18916372613 · [email protected]

深圳利斯康医药科技有限公司+86-755-89396905 +86-15013857715 · [email protected]

上海藜筠生物科技有限公司13119135307

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Compound notes

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