CAS 128439-50-9 Peptide oostatic hormone (HCID 5488810)

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Basic information

CAS: 128439-50-9
Standard SMILES: C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
InChIKey: BSVHTRRLCAVQCZ-JDEXMCKMSA-N
Molecular formula: C51H70N10O14
Average molar mass: 1,047.2 g/mol
Monoisotopic mass: 1,046.50729692

Overview

decapeptide which inhibits egg development in mosquitoes; from Aedes aegypti; modulates trypsin-like enzyme biosynthesis in the midgut

Names & identifiers

Preferred name: Peptide oostatic hormone
IUPAC: (2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
English name: oostatic factor, mosquito
Molecular formula: C51H70N10O14
Molecular weight: 1047.1601

Names & synonyms

128439-50-9TMOFH-Ydpapppppp-OHDTXSID40155902Tyrosyl-aspartyl-prolyl-alanyl-prolyl-prolyl-prolyl-prolyl-prolyl-prolineRefChem:171562DTXCID3078393Oostatic factor, mosquitoTMOF, mosquitoL-Tyrosyl-L-alpha-aspartyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-L-prolineH-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-OHMosquito oostatic factor

Show more names

Peptide oostatic hormoneTrypsin Modulating Oostatic Factor (TMOF)Trypsin-modulating oostatic factor (Aedes aegypti)L-Proline, L-tyrosyl-L-α-aspartyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-

Trypsin modulating oostatic factor, mosquitoSCHEMBL29362966BSVHTRRLCAVQCZ-JDEXMCKMSA-N(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acidNH2-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-COOH

Properties

Computed structural properties

XLogP: -2.8
Topological polar surface area: 321 Å²
Hydrogen bond donors: 6
Hydrogen bond acceptors: 15
Rotatable bonds: 16
Heavy atoms: 75
Formal charge: 0
Complexity: 2,240

Physicochemical properties

Boiling point: 1401.1 · 1401.1±65.0 °C(Predicted)
Density: 1.437 · 1.437±0.06 g/cm3(Predicted)
pka: 3.44 · 3.44±0.20(Predicted)

Chemistry & industry

Applications · 1 item

UsesL-Tyrosyl-L-α-aspartyl-L-prolyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-L-prolyl-L-proline is a larvicide useful for mosquito control. It can be used in the construction of plant expression vectors containing aedes aegypti TMOF analog genes, and their transformation to tobacco.