Alpidem

HCID 54897CAS 82626-01-5
Substructure searchFind similar structures

Basic information

Standard SMILES
CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12
InChIKey
JRTIDHTUMYMPRU-UHFFFAOYSA-N
Molecular formula
C21H23Cl2N3O
Average molar mass
404.3 g/mol
Monoisotopic mass
403.12181772

Overview

Alpidem is a member of imidazoles.

Names & identifiers

Preferred name
Alpidem
IUPAC
2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide
English name
Alpidem
Molecular formula
C21H23Cl2N3O
Molecular weight
404.33

Names & synonyms

ALPIDEM82626-01-5AlpidemumDTXSID8049046SL 80.0342-00I93SC245QZSL-80.0342-00DTXCID3028972SL 80-0342RefChem:555982Ananxyl2-(6-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide
Show more names
IMidazoinanxylSL-80．0342Unii-I93sc245qzALPIDEM USP/EP/BP
2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamideCHEMBL543496-Chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine-3-acetamideNCGC00182850-016-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamideImidazo(1,2-a)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-Alpidemum [Latin]

Database identifiers

CAS
82626-01-5
PubChem CID
54897
DTXSID
DTXSID8049046
ChEMBL
CHEMBL54349
ChEBI
CHEBI:135649
UNII
I93SC245QZ
EC Number
689-420-9
Nikkaji
J33.130I

Properties

Computed structural properties

XLogP
4.8
Topological polar surface area
37.6 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
2
Rotatable bonds
7
Heavy atoms
27

Physicochemical properties

Melting point
136 · 136-138°C
Density
1.24 · 1.24±0.1 g/cm3(Predicted)
storage temp.
Refrigerator
solubility
10 mg/mL · DMSO: ≥10mg/mL
pka
4.74 · 4.74±0.50(Predicted)
form
powder

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxicology

Drug Induced Liver Injury · 6 items

Drug Induced Liver Injury Rank (DILIrank 2.0)

Alpidem

vMost-DILI-concern

8

Withdrawn

DOI:10.1016/j.drudis.2016.02.015

Safety data

Signal word
Warning
Symbol(GHS)
GHS07
Hazard statements
H302
Precautionary statements
P280-P305+P351+P338

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 1 item

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.

Applications · 2 items

DescriptionAlpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.

UsesA peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic

Upstream & downstream products

Upstream raw materials

Suppliers23 total

泰州葛林美克医药科技有限公司15366892466
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]

Additional notes

DefinitionChEBI: Alpidem is a member of imidazoles.

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