Basic information
- CAS
82747-56-6- Standard SMILES
Cc1ncc2c(c1O)COC2c1ccc(Cl)cc1.Cl- InChIKey
QLMBAIRFQQLJJX-UHFFFAOYSA-N- Molecular formula
- C14H13Cl2NO2
- Average molar mass
- 298.2 g/mol
- Monoisotopic mass
- 297.032334
Overview
Cicletanine Hydrochloride is the hydrochloride salt of a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.
Names & identifiers
- Preferred name
- Cicletanine Hydrochloride
- IUPAC
- 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride
- English name
- Cicletanine hydrochloride
- Molecular formula
- C14H12ClNO2.ClH
- Molecular weight
- 298.168
Names & synonyms
CICLETANINE HYDROCHLORIDE82747-56-6Cicletanine HClT0SY6373OQWIN-90000 HCLWIN 90,000 HCLFuro(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, hydrochlorideRefChem:1261013-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochlorideCicletanine hydrochloride (JAN)Coverine
Show more names
JustarSecletanTenstaten3-(4-Chlorophenyl)-1,3-dihydro-6-methyl-furo[3,4-c]pyridin-7-ol Hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride (1:1)
3-(4-chlorophenyl)-6-methyl-1H,3H-furo[3,4-c]pyridin-7-ol hydrochlorideCICLETANINE HYDROCHLORIDE [JAN]Furosemide Impurity 22UNII-T0SY6373OQTenstaten (TN)Justar (TN)BN 1270SCHEMBL387011
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 42.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 294
Physicochemical properties
- Melting point
- 208 · 208-219°C
- storage temp.
- Refrigerator
- solubility
- Methanol
- form
- Solid
- color
- Pink
- FDA UNII
- 0 SY6373OQ · T0SY6373OQ
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H315
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
Warning
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (50%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H319-H315
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
Applications
DescriptionCicletanine is an antihypertensive diuretic indicated for the treatment of essential hypertension. Its unique mechanism of action is thought to involve the decrease of peripheral resistance and increase of venous compliance without modification of arterial diameter and venous tone. Chemically cicletanine belongs to a series of furopyridhes not associated with any currently known pharmacological classes.
UsesA new antihypertensive agent; exhibited a natriuretic effect comparable to that of hydrochlorothiazide and furosemide within 7 h. A furopyridine derivative with antihypertensive and diuretic properties.
Suppliers12 total
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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