Basic information
- CAS
83928-66-9- Standard SMILES
CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1.Cl- InChIKey
DGOCVISYYYQFEP-UHFFFAOYSA-N- Molecular formula
- C19H30ClN5O2
- Average molar mass
- 395.9 g/mol
- Monoisotopic mass
- 395.2088029
Overview
Gepirone hydrochloride is the hydrochloride salt of gepirone. It is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder. It has a role as an antidepressant, an anxiolytic drug and a serotonergic agonist. It contains a gepirone(1+).
Names & identifiers
- Preferred name
- Gepirone monohydrochloride
- IUPAC
- 4,4-dimethyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]piperidine-2,6-dione;hydrochloride
- English name
- Gepirone hydrochloride
- Molecular formula
- C19H30ClN5O2
- Molecular weight
- 395.9268
Names & synonyms
gepirone monohydrochlorideRefChem:142962GEPIRONE HYDROCHLORIDEGepirone HCl83928-66-9TravivoExxuaGepirone ERGepirone hydrochloride [USAN]BMY 13805-1Org 33062TGFK07AD
Show more names
RRSYY(Avadomide)-6GepironeHydrochloride2,6-Piperidinedione,4,4-dimethyl-1-[4-[4-(2- pyrimidinyl)-1-piperazinyl]butyl]-,monohydrochloride2,6-Piperidinedione, 4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, hydrochloride (1:1)
ORG-3306280C9L8EP6VCHEMBL1204187VarizaBMY-13805-14,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione hydrochlorideGepirone hydrochloride (USAN)3,3-Dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)glutarimide monohydrochloride
Database identifiers
- CAS
83928-66-9- PubChem CID
- 55190
- DTXSID
DTXSID30232812- ChEMBL
CHEMBL1204187
Properties
Computed structural properties
- Topological polar surface area
- 69.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 6
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 476
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 192.5 · 192.5-195.5 °C
- solubility
- 2 O: · H2O: 2 mg/mL, clear
- form
- powder
- color
- white to beige
- InChI
- InChI=1S/C19H29N5O2.ClH/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18;/h5-7H,3-4,8-15H2,1-2H3;1H
- InChIKey
- DGOCVISYYYQFEP-UHFFFAOYSA-N
- SMILES
- N1(CCCCN2CCN(C3=NC=CC=N3)CC2)C(=O)CC(C)(C)CC1=O.[H]Cl
- FDA UNII
- 80 C9L8EP6V · 80C9L8EP6V
- NACRES
- 28 · NA.28
- Symbol(GHS)
- 7 · GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- 302 · H302-H361
Safety & regulation
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS08
- Hazard statements
- H302-H361
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Applications
UsesTranquilizer.
Suppliers32 total
陕西凯尔凯医药科技有限公司029-2148545164 17392779578 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
奥夫仑医药（四川）有限公司17336178085 · [email protected]
成都佰洋科技有限责任公司02861777709 13308012069
济南启源生物科技有限公司18766124282; 18766124282 · [email protected]
Nantong Honglong Chemical Co., Ltd
Related reactions
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Compound notes
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