Basic information
- CAS
1082-57-1- Standard SMILES
c1cc2c(c(NC3=NCCN3)c1)CCCC2- InChIKey
QQJLHRRUATVHED-UHFFFAOYSA-N- Molecular formula
- C13H17N3
- Average molar mass
- 215.29 g/mol
- Monoisotopic mass
- 215.14224756
Overview
Tramazoline is a member of tetralins.
Names & identifiers
- Preferred name
- Tramazoline
- IUPAC
- N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
- English name
- Tramazoline
- Molecular formula
- C13H17N3
- Molecular weight
- 215.29
Names & synonyms
Tramazoline1082-57-1TramazolinaTramazolinumMuconasal4,5-Dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-1H-imidazol-2-amineSLE31693IV1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-2-(5,6,7,8-tetrahydro-1-naphthylamino)-2-imidazoline2-[(5,6,7,8-Tetrahydro-1-naphthyl)amino]-2-imidazoline2-((5,6,7,8-TETRAHYDRO-1-NAPHTHYL)AMINO)-2-IMIDAZOLINEBisolnasal
Show more names
2-imidazolin-2-yl(5,6,7,8-tetrahydro-1-naphthyl)amine2-(5,6,7,8-Tetrahydronaphthalen-1-ylamino)-2-imidazoline2-[(5,6,7,8-Tetrahydronaphthalen-1-yl)amino]-2-imidazoline
Spray-TishRefChem:190555R01AA09214-105-6N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amineCHEMBL32573Rhinol; Rhynaspray; TobisprayTramazoline (INN)
Database identifiers
- CAS
1082-57-1
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 36.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 274
Experimental & physicochemical properties
Drugs
Pharmaceuticals
Pharmaceuticals -> Listed in ZINC15
Human DrugsPharmaceuticals
Physicochemical properties
- Melting point
- 142 · 142-143 ºC
- Boiling point
- 353 · 353.0±52.0 °C(Predicted)
- Density
- 1.26 · 1.26
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.66 · pKa 10.66 (Uncertain)
- color
- White to Off-White
- FDA UNII
- 31693 IV · SLE31693IV
- ATC code
- 1 AA09 · R01AA09
- NIST Chemistry Reference
- 1 H-Imidazol-2-amine, · 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-(1082-57-1)
- Symbol(GHS)
- 7 · GHS07
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H332-H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
Chemistry & industry
Pharmacology
ATC Code
R01AA09
R - Respiratory system
QR - Respiratory system
MeSH Pharmacological Classification
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Uses & manufacturing
UsesUse (kg; approx.) in Germany (2009): >10
Use ClassificationPharmaceuticals
Applications
UsesTramazoline Acetate Salt is commonly used in nasal spray as a nasal decongestant by acting as an a-adrenergic receptor agonist that inhibits secretion of nasal mucus.
Suppliers7 total
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
芷威（上海）化学科技有限公司021-20221225 13917446399 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
AN PharmaTech Co Ltd86(21)68097365 · [email protected]
海蔚化学86-21-51086038 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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