Basic information
- CAS
749-13-3- Standard SMILES
O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1- InChIKey
GPMXUUPHFNMNDH-UHFFFAOYSA-N- Molecular formula
- C22H23F4NO2
- Average molar mass
- 409.4 g/mol
- Monoisotopic mass
- 409.16649162
Overview
Trifluperidol is an aromatic ketone.
Names & identifiers
- Preferred name
- Trifluperidol
- IUPAC
- 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one
- English name
- trifluperidol
- Molecular formula
- C22H23F4NO2
- Molecular weight
- 409.42
Names & synonyms
Trifluperidol749-13-3McN-JR-2498TrifluperidoloR-2498TrifluperidolumNSC-1709781-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-oneDTXSID4023703R8869Q7R8I1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-1-(4-Fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one
Show more names
trifluperidol USP/EP/BP1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one4-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)butyrophenone
1-(4-fluorophenyl)-4-{4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl}butan-1-one1-Butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-RefChem:933408DTXCID903703N05AD02PsicoperidolTrisedilPsychoperidol
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 40.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 537
Experimental & physicochemical properties
LogP2.27
Human DrugsPharmaceuticals
Physicochemical properties
- Boiling point
- 515.9 · 515.9±50.0 °C(Predicted)
- Density
- 1.2119 · 1.2119 (estimate)
- pka
- 13.87 · 13.87±0.20(Predicted)
- CAS DataBase Reference
- 749 · 749-13-3
- FDA UNII
- 8869 Q7R8I · R8869Q7R8I
- ATC code
- 5 AD02 · N05AD02
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesAntipsychotic.
UsesTrifluperidol is a powerful antipsychotic drug. It enhances the action of soporifics, narcotics, and analgesics. It also possesses anticonvulsant and antiemetic action. It is used in psychoses accompanied by motor and mental excitement, in prolonged attacks of recurrent schizophrenia, in cases accompanied by severe depression and delirium, and in alcoholic psychoses. It surpasses other neuroleptics in terms of its ability to stop minor manic excitement.
Suppliers
Related reactions
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Compound notes
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