Tripelennamine

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Concurrent use /of ototoxic medications/ with antihistamines may mask the symptoms of ototoxicity such as tinnitus, dizziness, or vertigo. /Antihistamines/

Concurrent use of monoamine oxidase (MAO) inhibitors with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines; concurrent use is not recommended. /Antihistamines/

Concurrent use /with alcohol or other CNS depression-producing medications/ may potentiate the CNS depressant effects of either these medications or antihistamines; also, concurrent use of maprotiline or tricyclic antidepressants may potentiate the anticholinergic effects of either antihistamines or these medications. /Antihistamines/

Anticholinergic effects may be potentiated when /anticholinergics or other medications with anticholinergic activity/ are used concurrently with antihistamines; patients should be advised to report occurrence of gastrointestinal problems promptly since paralytic ileus may occur with concurrent therapy. /Antihistamines/

For more Interactions (Complete) data for TRIPELENNAMINE (6 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. /Tripelennamine hydrochloride/ [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=154-69-8]

IN CASES OF SYSTEMIC POISONING FROM OVERDOSAGE, OCULAR EFFECTS HAVE BEEN RARE, BUT ISOLATED INSTANCES OF NYSTAGMUS & STRABISMUS HAVE BEEN NOTED, & PUPILS MAY BE DILATED & POORLY RESPONSIVE TO LIGHT.

UNUSUAL CASE OF POISONING BY PYRIBENZAMINE FOLLOWED PERCUTANEOUS APPLICATION OF 2.14 G OF DRUG AS AEROSOL SPRAY ON 8-YR-OLD BOY WITH SEVERE POISON IVY OF TRUNK & EXTREMITIES.

...RIGIDITY, STUPOR, & CIRCULATORY COLLAPSE ARE DESCRIBED IN HUMAN POISONINGS. /HYDROCHLORIDE/

...GI IRRITATION IS COMMON, BUT NOT SEVERE; SEDATION IS MODERATE, & CNS STIMULATION OCCURS OCCASIONALLY. /HYDROCHLORIDE/

For more Human Toxicity Excerpts (Complete) data for TRIPELENNAMINE (13 total), please visit the HSDB record page.

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

tripelennamine

DILI Positive

Topical, Oral, vaginal

DOI:10.1016/j.drudis.2019.09.022

THERE IS NO SPECIFIC THERAPY FOR ANTIHISTAMINE POISONING, AND TREATMENT IS ALONG GENERAL SYMPTOMATIC AND SUPPORTIVE LINES. ... SHOULD BREATHING FAIL, MECH SUPPORT OF VENTILATION OFFER SAFER AND ... EFFECTIVE MEANS OF MAINTAINING RESP THAN USE OF ANALEPTICS WHICH ARE PRONE TO INITIATE OR INTENSIFY CONVULSIVE PHASE. /ANTIHISTAMINES/

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

SUNBURN TREATMENT

MEDICATION

MEDICATION (VET)

Use (kg; approx.) in Germany (2009): >25

(1977) 4.50X10+5 G-PRINCPL CUSTMS DISTS-AS HYDROCHLORIDE

(1979) 9.50X10+5 G-PRINCPL CUSTMS DISTS-AS HYDROCHLORIDE

(1977) GREATER THAN 1.36X10+6 G-INCL SALTS

(1979) GREATER THAN 9.08X10+5 G-INCL CITRATE

REACTION OF O-AMINOPYRIDINE AND BETA-DIMETHYLAMINOETHYL CHLORIDE IN THE PRESENCE OF SODAMIDE FOLLOWED BY CONDENSATION WITH BENZYL BROMIDE

...BY SODAMIDE CONDENSATION OF N,N-DIMETHYLAMINOETHYL-2-AMINOPYRIDINE WITH DIMETHYLAMINOETHYL CHLORIDE.

TRIPELENNAMINE IS REACTED WITH EQUIMOLAR PORTION OF CITRIC ACID IN SUITABLE SOLVENT WHICH MAY THEN BE REMOVED BY EVAPORATION. /CITRATE/

TRIPELENNAMINE MAY BE PREPARED AS FOLLOWS: O-AMINOPYRIDINE, PREPARED BY ACTION OF SODAMIDE ON PYRIDINE, IS REACTED WITH BETA-DIMETHYLAMINOETHYL CHLORIDE IN PRESENCE OF SODAMIDE, & RESULTING 2-[2-(DIMETHYLAMINO)ETHYLAMINO]PYRIDINE IS CONDENSED WITH BENZYLBROMIDE IN PRESENCE OF SODAMIDE. /HYDROCHLORIDE/

HYDROCHLORIDE IS FORMED FROM BASE BY TREATMENT WITH HYDROGEN CHLORIDE IN ORG SOLVENT. /HYDROCHLORIDE/

ELIXIR 37.5 MG (EQUIV TO 25 MG OF HYDROCHLORIDE SALT)/5 ML. /CITRATE/

GENERIC: TABLETS, POWDER, CREAM; PBZ-SR (GEIGY) TABLETS (TIMED-RELEASE) 100 MG; PYRIBENZAMINE HYDROCHLORIDE (CIBA): TABLETS 25 & 50 MG, TABLETS (TIMED-RELEASE) 50 MG, CREAM 2% IN 1 OZ CONTAINERS, OINTMENT 2% IN 1 OZ CONTAINERS. /HYDROCHLORIDE/