Basic information
- CAS
91776-47-5- Standard SMILES
COC1=CC(=O)c2c(cc(OC)c(CSC[C@H](NC(C)=O)C(=O)O)c2O)C1=O- InChIKey
PBMJDDQAEYEYKK-NSHDSACASA-N- Molecular formula
- C18H19NO8S
- Average molar mass
- 409.4 g/mol
- Monoisotopic mass
- 409.08313774
Overview
Fibrostatin C is a N-acyl-L-amino acid.
Names & identifiers
- Preferred name
- Fibrostatin C
- IUPAC
- (2R)-2-acetamido-3-[(1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methylsulfanyl]propanoic acid
- English name
- fibrostatin C
- Molecular formula
- C18H19NO8S
- Molecular weight
- 409.413
Names & synonyms
Fibrostatin C91776-47-5(2R)-2-acetamido-3-[(1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methylsulfanyl]propanoic acidL-Cysteine, N-acetyl-S-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)-(2R)-2-acetamido-3-((1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methylsulfanyl)propanoic acidRefChem:140391N-Acetyl-S-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)-L-cysteineorb1703449DTXSID20919529CHEBI:221943AKOS040745792N-acetyl-S-((1-hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl)-L-cysteine
Show more names
P-23924CN-Acetyl-S-[(5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methyl]-L-cysteine
HY-129502T24062(2R)-2-acetamido-3-[(1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methylsulanyl]propanoic acidS-[(1-Hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl]-N-(1-hydroxyethylidene)-L-cysteineS-[(1-Hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl]-N-(1-hydroxyethylidene)cysteine
Database identifiers
- CAS
91776-47-5- PubChem CID
- 56296
- DTXSID
DTXSID20919529- ChEBI
CHEBI:221943- Nikkaji
- J128.637D
Properties
Computed structural properties
- XLogP
- 1.2
- Topological polar surface area
- 165 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 8
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 678
Chemistry & industry
Applications
DescriptionFibrostatin C is a prolyl 4-hydroxylase (PH) inhibitor produced by Streptomyces catenulae subsp. griseospora.
UsesFibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery[1][2].
Suppliers3 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
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Compound notes
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