Triprolidine Hydrochloride Anhydrous
Basic information
- CAS
550-70-9- Standard SMILES
Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl- InChIKey
WYUYEJNGHIOFOC-NWBUNABESA-N- Molecular formula
- C19H23ClN2
- Average molar mass
- 314.9 g/mol
- Monoisotopic mass
- 314.1549764
Overview
Triprolidine hydrochloride (anh.) is a hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It contains a triprolidine(1+).
Names & identifiers
- Preferred name
- Triprolidine Hydrochloride Anhydrous
- IUPAC
- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride
- English name
- trans-Triprolidine hydrochloride
- Molecular formula
- C19H23ClN2
- Molecular weight
- 314.85
Names & synonyms
Triprolidine hydrochloride550-70-9Triprolidine HCLTriprolidine hydrochloride anhydrousTriprolidine Hydrochloride (anhydrous)MyidylNG7A104R3JPyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, (E)-DTXSID10872513NSC-757361Triprolidine MonohydrochlorideHistex
Show more names
VenenEntraActidil295 C 51ActidilatPro-entraActidilonPro-actidilEinecs 208-985-0
Histex Pd DropsMiclara LQHISTEX PDX DropsTriprolidine HCl DropsChildrens PediaClear PDRefChem:56181Hydrochloride, TriprolidineDTXCID00820164
Database identifiers
- CAS
550-70-9、6138-79-0- PubChem CID
Properties
Computed structural properties
- Topological polar surface area
- 16.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 335
Experimental & physicochemical properties
Solubility>47.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
Breast Feeding; Lactation; Milk, Human; Antihistamines
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section169 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 116 · 116-118 °C
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), Water (Slightly)
- form
- Powder
- Water Solubility
- 100 mM · Soluble to 100 mM in water
- Stability
- Hygroscopic
- CAS DataBase Reference
- 550 · 550-70-9(CAS DataBase Reference)
- FDA UNII
- 7 A104R3J · NG7A104R3J
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 4 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Other Safety InformationIMAP assessments - Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, (E)-: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Triprolidine hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Safety data
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- UT7658000
- ridadr
- 3249
- Toxicity
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Uses & manufacturing
General Manufacturing InformationPyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-, hydrochloride (1:1): INACTIVE
Applications
Usestrans-Triprolidine Hydrochloride is a histamine H1 receptor antagonist, which can be used for the prevention of treatment of chronic muscle pain.
UsesTriprolidine is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.
UsesAntihistaminic;H1 antagonist
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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