Eticlopride
Basic information
- CAS
84226-12-0- Standard SMILES
CCc1cc(Cl)c(OC)c(C(=O)NC[C@@H]2CCCN2CC)c1O- InChIKey
AADCDMQTJNYOSS-LBPRGKRZSA-N- Molecular formula
- C17H25ClN2O3
- Average molar mass
- 340.8 g/mol
- Monoisotopic mass
- 340.1553704
Overview
5-chloro-3-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide is a member of salicylamides.
Names & identifiers
- Preferred name
- Eticlopride
- IUPAC
- 5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
- English name
- S(-)-eticlopride hydrochloride
- Molecular formula
- C17H25ClN2O3
- Molecular weight
- 340.85
Names & synonyms
EticloprideEticlopridaEticlopridum84226-12-0J8M468HBH45-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamideFLB-1313-Chloro-5-Ethyl-N-{[(2s)-1-Ethylpyrrolidin-2-Yl]methyl}-6-Hydroxy-2-MethoxybenzamideDTXSID90484355-chloro-3-ethyl-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide3-chloro-5-ethyl-N-(((2S)-1-ethylpyrrolidin-2-yl)methyl)-6-hydroxy-2-methoxybenzamide5-chloro-3-ethyl-N-(((2S)-1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide
Show more names
FLB 131s(-)-eticloprideETICLOPRIDE HYDROCHLORIDES(-)-eticlopride hydrochloride3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxybenzamideS(-)-3-CHLORO-5-ETHYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]6-HYDROXY-2 METHOXYBENZAMIDE HCLBenzamide, 3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-(-)-3-Chloro-5-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-6-hydroxy-2-methoxybenzamideS(-)-3-CHLORO-5-ETHYL-N-([1-ETHYL-2-PYRROLIDINYL]METHYL)-6-HYDROXY-2-METHOXYBENZAMIDE HYDROCHLORIDE
Properties
Computed structural properties
- XLogP
- 3.1
- Topological polar surface area
- 61.8 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 396
Experimental & physicochemical properties
Collision Cross Section165.89 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- solubility
- 2 O: · H2O: 12 mg/mL, soluble
- color
- off-white
- FDA UNII
- 8 M468HBH4 · J8M468HBH4
- Comptox DTXSID
- 9048435 · DTXSID9048435
- WGK Germany
- 3 · 3
- RTECS
- 2450000 · CV2450000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- CV2450000
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Applications
UsesR (+)-Eticlopride is a dopamine D2-receptor antagonist.
Additional notes
DefinitionChEBI: 5-chloro-3-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide is a member of salicylamides.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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