Basic information
- CAS
51-63-8- Standard SMILES
C[C@H](N)Cc1ccccc1.C[C@H](N)Cc1ccccc1.O=S(=O)(O)O- InChIKey
PYHRZPFZZDCOPH-QXGOIDDHSA-N- Molecular formula
- C18H28N2O4S
- Average molar mass
- 368.5 g/mol
- Monoisotopic mass
- 368.17697855
Overview
Dextroamphetamine Sulfate is the salt of the dextro-isomer of amphetamine and sympathomimetic amine with CNS stimulating properties. Dextroamphetamine sulphate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of narcolepsy and attention deficit hyperactivity disorder.
Names & identifiers
- Preferred name
- Dextroamphetamine Sulfate
- IUPAC
- bis((2S)-1-phenylpropan-2-amine);sulfuric acid
Names & synonyms
Dextroamphetamine sulfateDexampexDextrostatFerndexDextroamphetamine sulphateDexamphetamine sulfateDexamphetamine sulphated-Amphetamine sulphateD-Amphetamine hemisulfate salt(+)-Amphetamine sulphateDexamfetamine sulfateDextroamphetamine Sulfate CII
Show more names
Dextro-Amphetamine SulfateDTXSID2057865JJ768O327Nd-alpha-Methylphenethylamine sulfateNSC-27104Dextro-beta-phenylisopropylamine sulfateDextro-alpha-methylphenethylamine sulfate(S)-alpha-Methylbenzeneethanamine sulfate
Database identifiers
- CAS
51-63-8- PubChem CID
- 5825
- DTXSID
DTXSID2057865- ChEMBL
CHEMBL3544971- UNII
- JJ768O327N
- EC Number
- 200-111-6
Properties
Computed structural properties
- Topological polar surface area
- 135 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 166
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationDextroamphetamine sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (97.9%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Dextroamphetamine sulfate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
DEXTROAMPHETAMINE SULFATE
Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
Related reactions
1 records
Compound notes
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