Rufloxacin

HCID 58258
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Basic information

CAS
101363-10-4
Standard SMILES
CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2SCC4)CC1
InChIKey
NJCJBUHJQLFDSW-UHFFFAOYSA-N
Molecular formula
C17H18FN3O3S
Average molar mass
363.4 g/mol
Monoisotopic mass
363.10529066

Overview

Rufloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

Names & identifiers

Preferred name
Rufloxacin
IUPAC
7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

Names & synonyms

Rufloxacin101363-10-4RufloxacineRufloxacinoRufloxacinumMF 934MonosNSC-7598357-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acidY521XM2900DTXSID6048412Tebraxin
Show more names
9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7h-[1,4]thiazino[2,3,4-ij]quinoline-6-carboxylic acidrufloxacinaUroflox7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo(7.3.1.0^(5,13))trideca-5(13),6,8,11-tetraene-11-carboxylic acid7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo(7.3.1.05,13)trideca-5(13),6,8,11-tetraene-11-carboxylic acid7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid9-fluoro-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-(1,4)thiazino(2,3,4-ij)quinoline-6-carboxylic acidRefChem:180288

Database identifiers

CAS
101363-10-4
PubChem CID
58258
DTXSID
DTXSID6048412
ChEMBL
CHEMBL295619
ChEBI
CHEBI:8909
UNII
Y521XM2900
EC Number
842-241-1
Nikkaji
J365.971B

Properties

Computed structural propertiesFilling in

XLogP
-0.3
Topological polar surface area
89.4 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
8
Rotatable bonds
2
Heavy atoms
25

Experimental & physicochemical properties

Drugs · 3 items

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Listed in ZINC15

Pharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic use

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Chemistry & industry

Pharmacology

ATC Code · 2 items

J - Antiinfectives for systemic use

QJ - Antiinfectives for systemic use

Mechanism of ActionRufloxacin is a fluoroquinolone antibacterial that inhibits bacterial DNA gyrase, blocking DNA supercoiling and replication.
MeSH Pharmacological Classification · 1 item

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

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Compound notes

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