Basic information
- CAS
53-46-3- Standard SMILES
CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21.[Br-]- InChIKey
PQMWYJDJHJQZDE-UHFFFAOYSA-M- Molecular formula
- C21H26BrNO3
- Average molar mass
- 420.3 g/mol
- Monoisotopic mass
- 419.10961
Overview
Methantheline bromide is a member of xanthenes.
Names & identifiers
- Preferred name
- Methantheline Bromide
- IUPAC
- diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
- English name
- METHANTHELINE BROMIDE
- Molecular formula
- CH3-
- Molecular weight
- 15.03452
Names & synonyms
METHANTHELINE BROMIDE53-46-3BanthineVagantinMethanthelinium bromideDixamone bromideDTXSID7023277NSC-32145090519SAPFDTXCID603277Ethanaminium, N,N-diethyl-N-methyl-2-((9H-xanthen-9-ylcarbonyl)oxy)-, bromideRefChem:57334
Show more names
Methanthelinemtb51sc2910ulcineavagalmetaxanvagaminBantosal
200-176-0FrenogastricoGastrosedanResobantinUlcudexterAsabaineBanthinDoladene
Database identifiers
- CAS
53-46-3- PubChem CID
- 5883
- DTXSID
DTXSID7023277- ChEMBL
CHEMBL1200988- ChEBI
CHEBI:6818- UNII
- 090519SAPF
- EC Number
- 200-176-0
Properties
Computed structural properties
- Topological polar surface area
- 35.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 426
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 175 · 175-176°
- Density
- 1.338 · 1.3380 (rough estimate)
- refractive index
- 1.62 · 1.6200 (estimate)
- storage temp.
- -20 °C · -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Dark Orange to Very Dark Orange
- FDA UNII
- 90519 SAPF · 090519SAPF
- ATC code
- 3 AB07 · A03AB07
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H332
- Precautionary statements
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P301+P317, P304+P340, P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Safety data
- Toxicity
- LD50 i.p. in mice: 76 mg/kg (Hambourger)
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H332
- Precautionary statements
- P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Applications
UsesUlcine is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.
UsesMETHANTHELINE BROMIDE is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.
General DescriptionMethanthelinebromide, diethyl(2-hydroxyethyl)methylammonium bromidexanthene-9-carboxylate (Banthine Bromide), is awhite, slightly hygroscopic, crystalline salt that is solublein water to produce solutions with a pH of about 5.Aqueous solutions are not stable and hydrolyze in a fewdays. The bromide form is preferable to the very hygroscopicchloride.Among the conditions for which methantheline bromideis indicated are gastritis, intestinal hypermotility, bladderirritability, cholinergic spasm, pancreatitis, hyperhidrosis,and peptic ulcer, all of which are manifestations ofparasympathotonia.
Suppliers17 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Shaanxi LonierHerb Bio Technology Co Ltd+86-86-+86-86-029-87551862 15002946897 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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