Basic information
- CAS
53-73-6- Standard SMILES
CC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C- InChIKey
JYPVVOOBQVVUQV-UHFFFAOYSA-N- Molecular formula
- C49H70N14O11
- Average molar mass
- 1,031.2 g/mol
- Monoisotopic mass
- 1,030.5348491
Names & identifiers
- Preferred name
- Hypertensinamide
- IUPAC
- 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[(2,4-diamino-4-oxobutanoyl)amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
- English name
- Asn-Arg-Val-Tyr-Val-His-Pro-Phe
- Molecular formula
- C49H70N14O11
- Molecular weight
- 1031.17
Names & synonyms
Angiotensin II amideHypertensineHypertensinamideAngiotensin II-amideVal-5-angiotensin II amide5-Valyl-angiotensin II amide5-Valine angiotensin II amide5-Valine-angiotensin amide IIAngiotensin II amide 5-valineAngiotensin II-5-valine amideAngiotensin amide, 5-L-valine-5-L-Valine-angiotensin II amide
Show more names
angiotensinamideAngiotensin amide acetate(ASN1,VAL5)-ANGIOTENSIN II(Asn?,Val?)-Angiotensin IIhypertensin II, 1-amide-5-valylAsn-Arg-Val-Tyr-Val-His-Pro-PheL-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHEH-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH[ASN1,VAL5]-ANGIOTENSIN II ACOH 4H2OH2-ASN-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH
Angiotensin II amide, 5-L-valine-1-Asparagine-5-valine-angiotensin II1-Asparaginyl-5-valyl-angiotensin II1-Asparatic acid-5-valine-angiotensin II amideAngiotensinamide (INN)C49H70N14O11Angiotensinamid[1-Asparagine-5-valine]-angiotensin II
Properties
Computed structural properties
- XLogP
- -2.7
- Topological polar surface area
- 415 Ų
- Hydrogen bond donors
- 13
- Hydrogen bond acceptors
- 14
- Rotatable bonds
- 28
- Heavy atoms
- 74
- Formal charge
- 0
- Complexity
- 1,960
Physicochemical properties
- Density
- 1.45 · 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -15 °C · -15°C
- pka
- 3.56 · 3.56±0.10(Predicted)
- FDA UNII
- 7 WAL1X78KV · 7WAL1X78KV
- ATC code
- 1 CX06 · C01CX06
Chemistry & industry
Applications
General DescriptionAngiotensin amide (Hypertensin)is a synthetic polypeptide (1-L-aspariginyl-5-L-valine angiotensinoctapeptide) and has twice the pressor activity ofangiotensin II. It is pharmaceutically available as alyophilized powder for injection (0.5–2.5 mg diluted in500 mL of sodium chloride injection or 5% dextrose for injection)to be administered by continuous infusion. The pressoreffect of angiotensin is due to an increase in peripheralresistance; it constricts resistance vessels but has little or nostimulating action on the heart and little effect on the capacitancevessels. Angiotensin has been used as an adjunct invarious hypotensive states. It is mainly useful in controllingacute hypotension during administration of general anestheticsthat sensitize the heart to the effects of catecholamines.
Upstream & downstream products
Upstream raw materials
Suppliers45 total
湖北强耀生物科技有限公司18301728382 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
中科华药(江苏)生物科技有限公司18020125070 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
Related reactions
0 records
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Compound notes
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