Phytohemagglutinins
Basic information
- CAS
9008-97-3- Standard SMILES
COc1cc(OC)c2c(c1)OC(c1ccc(OC)c(OC)c1)CC2O- InChIKey
APLKIOPSKVXHFK-UHFFFAOYSA-N- Molecular formula
- C19H22O6
- Average molar mass
- 346.4 g/mol
- Monoisotopic mass
- 346.14163842
Overview
Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.
Names & identifiers
- Preferred name
- Phytohemagglutinins
- IUPAC
- 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-4-ol
- English name
- PHYTOHEMAGGLUTININ PHA-M
- Molecular weight
- 0
Names & synonyms
Phytohemagglutinins9008-97-3Plant HemagglutininsHemagglutinins, PlantRefChem:389217Lectin2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-4-olLectin from Phaseolus vulgaris (red kidney bean)2-(3,4-Dimethoxyphenyl)-3,4-dihydro-5,7-dimethoxy-2H-1-benzopyran-4-ol2H-1-Benzopyran-4-ol, 2-(3,4-dimethoxyphenyl)-3,4-dihydro-5,7-dimethoxy-2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4-chromanol #10496-69-2
Show more names
PHA-LPHA-PPHASEOLUS VULGARIS LEUCOAGGLUTININPHA-CPHA-MDog PHAPHA-P PHA-LPhytolectinPHA proteinfitohemaglutynina
Database identifiers
Properties
Computed structural properties
- XLogP
- 2.6
- Topological polar surface area
- 66.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 5
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 419
Experimental & physicochemical properties
Chemical ClassesBiological Agents -> Plant Toxins
Physical DescriptionPowder; [Sigma-Aldrich MSDS]
Physicochemical properties
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- 2 mg/mL · PBS: 2 mg/mL
- form
- salt-free, lyophilized powder
- color
- White to light yellow
- biological source
- Phaseolus vulgaris
- Cosmetics Ingredients Functions
- SKIN CONDITIONING - MISCELLANEOUS
- EWG's Food Scores
- 1 · 1
- NCI Dictionary of Cancer Terms
- phytohemagglutinin
- FDA UNII
- 3 EXR62A · GJY3EXR62A
- UNSPSC Code
- 23201100 · 23201100
- NACRES
- 56 · NA.56
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory InformationAgglutinins and Lectins, phytohemagglutinins: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Safety data
- F
- 10-21
- wgk
- WGK 3
- rtecs
- TJ3470000
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
A substance that makes particles (such as bacteria or cells) stick together to form a clump or a mass.
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)
Applications
UsesPhytohemagglutinin-M (PHA-M) has been used in the activation of Jurkat and primary cells. It has also been used to treat polymorphonuclear blood cells(PMBCs)
General DescriptionLectins are distinct proteins or glycoproteins that have at least one non-catalytic domain which fixes reversibly to a definite mono- or oligosaccharide. Some of their potentially utilizable biological assets include: antitumor, immunomodulatory and anti-insect, antifungal, antibacterial, anti-HIV, and mitogenic properties.
Related reactions
0 records
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Compound notes
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