Fadrozole (HCID 59693)

Names & identifiers

Preferred name: Fadrozole
IUPAC: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
English name: FADROZOLE
Molecular formula: C14H13N3
Molecular weight: 223.27

Names & synonyms

FADROZOLE102676-47-14-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrileFadrozolFadrozolumBenzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-DTXSID5034141H3988M64PUCGS020286ABenzonitrile, 4-(5,6,7,8-tetrahydroimidazo(1,5-a)pyridin-5-yl)-4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile4-(5,6,7,8-tetrahydroimidazo(5,1-f)pyridin-5-yl)benzonitrile

Show more names

AfemaCS-2710FAD 286)CGS-16949CGS-169494FADROZOLE USP/EP/BPFadrozole (CGS 16949AFadrozole, 10 mM in DMSO

4-(5,6,7,8-tetrahydroimidazo[5,1-f]pyridin-5-yl)benzonitrileFAD286CGS-020286ARefChem:597144DTXCID3014141CGS16949AFAD-286Fadrozole [INN]

Database identifiers

CAS: 102676-47-1
PubChem CID: 59693
DTXSID: DTXSID5034141
ChEMBL: CHEMBL9298
ChEBI: CHEBI:94355
UNII: H3988M64PU
EC Number: 862-508-6
Nikkaji: J366.696D

Properties

Computed structural properties

XLogP: 2.1
Topological polar surface area: 41.6 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 17
Formal charge: 0
Complexity: 311

Experimental & physicochemical properties

Collision Cross Section · 1 item

157.2 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4020618]；157.0 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID4020618]；157.3 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID5034141]

Physicochemical properties

Melting point: 0 °C · 0°C
Boiling point: 0 °C · 0°C
Density: 1.2 · 1.20
Flash point: 0 °C · 0°C
storage temp.: 2 · 2-8°C
solubility: 100 mg/mL · DMSO : ≥ 100 mg/mL (447.89 mM)
form: Solid
pka: 7.16 · 7.16±0.40(Predicted)
color: White to off-white
FDA UNII: 3988 M64PU · H3988M64PU
EPA Substance Registry System: 4 · Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- (102676-47-1)
Symbol(GHS): 6 · GHS06,GHS08
Signal word: Danger
Hazard statements: 301 · H301-H361
Precautionary statements: 281 · P281-P301+P310
Risk Statements: 20 · 20/21/22
Safety Statements: 22 · 22-24/25
RIDADR: 3439 · 3439

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Acute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；Acute Tox. 4 (100%)；STOT SE 3 (100%)

Toxicology

USGS Health-Based Screening Levels for Evaluating Water-Quality · 3 items

Fadrozole

Pharmaceutical

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Safety data

ridadr: 3439
risk_code: 20/21/22
Signal word: Danger
Symbol(GHS): GHS06,GHS08
safety_code: 22-24/25
Hazard statements: H301-H361
Precautionary statements: P281-P301+P310

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 3 items

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)

Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.