Basic information
- CAS
12789-03-6- Standard SMILES
ClC1=C(Cl)C2(Cl)C3C(Cl)C(Cl)CC3C1(Cl)C2(Cl)Cl- InChIKey
BIWJNBZANLAXMG-UHFFFAOYSA-N- Molecular formula
- C10H6Cl8
- Average molar mass
- 409.8 g/mol
- Monoisotopic mass
- 405.797772
Overview
Chlordane can cause cancer according to an independent committee of scientific and health experts.
Names & identifiers
- Preferred name
- Chlordane, technical
- IUPAC
- 1,3,4,7,8,9,10,10-octachlorotricyclo[5.2.1.02,6]dec-8-ene
- English name
- photochlordane
- Molecular formula
- C10H6Cl8
- Molecular weight
- 409.78
Names & synonyms
Technical chlordaneChlordane, technical4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-Caswell No. 174ECCRIS 854DTXSID5023954RefChem:575593687-155-312789-03-6ChlordanceChlor KilC10H6Cl8
Show more names
1,5:2,4-Dimethanopentalene, 1,2,5,6,6,6a,7,8-octachlorooctahydro-, (1R,2S,3aS,4S,5R,6aS,7R,8R)-rel- (9CI)1,5:2,4-Dimethanopentalene, 1,2,5,6,6,6A,7,8-octachlorooctahydro-, (1alpha,2alpha,3aalpha,4beta,5alpha,6aalpha,7R*,8R*)-
33442-85-2.gamma.-ChlordanPhotochlordaneChlordane, technical gradecis-PhotochlordaneChlordane-technicalChlordane (mixture of isomers)Chlordane, liquid
Database identifiers
- CAS
12789-03-6、33442-85-2、57-74-9- PubChem CID
- 5993
- DTXSID
DTXSID7020267- ChEMBL
CHEMBL196537- ChEBI
CHEBI:34623- EC Number
- 687-155-3
- Nikkaji
- J4.407E
Properties
Computed structural properties
- XLogP
- 4.9
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 0
- Rotatable bonds
- 0
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 459
Experimental & physicochemical properties
PesticidesPesticide
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Boiling point
- 407.2 · 407.2±40.0 °C(Predicted)
- Density
- 1.9 · 1.90±0.1 g/cm3(Predicted)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302+H312 (100%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]
P203, P264, P270, P273, P280, P301+P317, P302+P352, P317, P318, P321, P330, P362+P364, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Other Safety InformationIMAP assessments - 4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety & protection
Minimum Risk LevelIntermediate Inhalation: 0.0002 mg/m3 (L134)
Chronic Inhalation: 0.00002 mg/m3 (L134)
Acute Oral: 0.001 mg/kg/day (L134)
Intermediate Oral: 0.0006 mg/kg/day (L134)
Chronic Oral: 0.0006 mg/kg/day (L134)
Toxicology
TreatmentTreatment is symptomatic. It is aimed at controlling convulsions, coma, and respiratory depression. Gastric lavage, followed by the administration of activated charcoal, may be performed following ingestion. (L146)
Health Effects
Chlordane is a central nervous system stimulant, and can also damage the digestive system and the liver. Large doses have been known to cause convulsions, respiratory failure, and death. Chlordane is also known to have adverse reproductive and developmental effects. (L91)
Exposure RoutesOral (L281) ; inhalation (A105)
Toxicity Summary
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related receptors. Chlordane induces hepatic cytochrome P-450, causing a large increase in the volume of the smooth endoplasmic reticulum, which results in hepatocellular enlargement and hypertrophy. Chlordane has also been shown to bind and activate retinoic acid receptor, causing various developmental defects, and inhibit alkaline phosphatases in hepatic and renal tissues. (L91, A52, A53, A68, A69)
Signs and SymptomsIngestion and inhalation of chlordane cause headaches, irritability, confusion, weakness, vision problems, vomiting, stomach cramps, diarrhea, and jaundice. (L91)
Carcinogen Classification2B, possibly carcinogenic to humans. (L135)
Toxicity DataLD50: 200 mg/kg (Oral, Rat) (T13)
LD50: 343 mg/kg (Intraperitoneal, Rat) (T13)
LD50: 10 mg/kg (Intravenous, Mouse) (T14)
LD50: 780 mg/kg (Dermal, Rat) (T14)
LC50: 100 mg/m3 over 4 hours (Inhalation, Cat) (T14)
RAIS Toxicity Values
0.0001
IRIS Current
0.0007
IRIS Current
0.0002
ATSDR Final
USGS Health-Based Screening Levels for Evaluating Water-Quality
Chlordane, technical
Pesticide
2
Applies to chlordane, CASRN 12798036
Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP
Hazard Quotient Level 0.1 or Cancer Risk Level 1E-06
1.70e+00
7.70e+00
2.80e-02
1.20e-01
2.00e-02
2.00e+00
Hazard Quotient Level 3 or Cancer Risk Level 1E-04
1.00e+02
7.70e+02
2.20e+00
9.20e+00
2.00e+00
2.00e+00
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Chlordane is highly lipophilic and is thus easily absorbed by ingestion, inhalation, and dermal exposure, then stored mainly in the fat. Chlordane is metabolized mainly in the liver and kidney. Metabolism is slow, and is believed to occur by multiple pathways involving cytochrome P-450 enzymes, glutathione-S-transferase type enzymes, and microsomal mixed-function oxidase systems. The metabolites are generally less toxic and include chlordene chlorohydrin, monohydroxylated dihydrochlordene, and oxychlordane. They are excreted in the urine and faeces. (L91)
Uses & manufacturing
UsesChlordane was used as a pesticide. (L90)
Additional notes
DefinitionChEBI: Chlordane is a cyclodiene organochlorine insecticide. It has a role as a GABA-gated chloride channel antagonist and a persistent organic pollutant. It derives from a hydride of an indene.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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