Temafloxacin Hydrochloride
Basic information
- CAS
105784-61-0- Standard SMILES
CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1.Cl- InChIKey
DDVJEYDLTXRYAJ-UHFFFAOYSA-N- Molecular formula
- C21H19ClF3N3O3
- Average molar mass
- 453.8 g/mol
- Monoisotopic mass
- 453.1067037
Overview
See also: Temafloxacin (has active moiety).
Names & identifiers
- Preferred name
- Temafloxacin Hydrochloride
- IUPAC
- 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
- English name
- TEMAFLOXACIN HYDROCHLORIDE
- Molecular formula
- C21H18F3N3O3.ClH
- Molecular weight
- 453.846
Names & synonyms
TEMAFLOXACIN HYDROCHLORIDE105784-61-0Temafloxacin HClOC5IGJ7J6IABBOTT-62254tefloxOmnifioxTeflox 400RefChem:9326931-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, hydrochlorideTemafloxacin (hydrochloride)Temafloxacin hydrochloride [USAN]
Show more names
Abbott 622541-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-Quinolinecarboxylic acid hydrochloride3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)
SCHEMBL134293TEMAFLOXACINHYDROCHLORIDE1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)-UNII-OC5IGJ7J6IOmniflox (TN)BCP26073
Database identifiers
- CAS
Properties
Computed structural properties
- Topological polar surface area
- 72.9 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 3
- Heavy atoms
- 31
- Formal charge
- 0
- Complexity
- 721
Physicochemical properties
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 2 mg/ml · ≤2mg/ml in DMSO;5mg/ml in dimethyl formamide
- form
- crystalline solid
- FDA UNII
- 5 IGJ7J6I · OC5IGJ7J6I
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H332-H335
- Precautionary statements
- 261 · P261-P280-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that inhibit the growth or reproduction of BACTERIA.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
Applications
DescriptionTemafloxacin hydrochloride is a new fluoroquinolone antibacterial structurally and mechanistically related to tosufloxacin, another microbial DNA topoisomerase inhibitor introduced in 1990. It is particularly useful against beta-lactamase producing organisms and is indicated for the treatment of respiratory and urinary tract infections as well as sexually transmitted diseases, skin and soft tissue infections. The compound has high tissue penetration and is reported to have a low propensity to cause adverse effects and drug interactions.
UsesTemafloxacin Hydrochloride is an antimicrobial quinolone drug.
UsesAntibacterial (microbial DNA topoisomerase inhibitor).
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