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Basic information
- CAS
108319-06-8- Standard SMILES
CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1- InChIKey
QKDHBVNJCZBTMR-UHFFFAOYSA-N- Molecular formula
- C21H18F3N3O3
- Average molar mass
- 417.387 g/mol
- Monoisotopic mass
- 417.1300261
Names & identifiers
- Preferred name
- Temafloxacin
- IUPAC
- 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- English name
- TEMAFLOXACIN
- Molecular formula
- C21H18F3N3O3
- Molecular weight
- 417.38
Names & synonyms
TefloxA-63004A-62254OmnifloxAKOS 92085TEMAFLOXACINTeMafloxacin HClTEMAFLOXACIN USP/EP/BPTemafloxacin (Omniflox)6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Database identifiers
- CAS
108319-06-8- PubChem CID
- 60021
- DTXSID
DTXSID7044132- ChEMBL
CHEMBL277100- ChEBI
CHEBI:77796- UNII
- 1WZ12GTT67
- Nikkaji
- J345.988H
Properties
Physicochemical properties
- Melting point
- 200 °C · >200°C (dec.)
- Boiling point
- 608.9 · 608.9±55.0 °C(Predicted)
- Density
- 1.3372 · 1.3372 (estimate)
- storage temp.
- 2 · 2-8°C(protect from light)
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.02 · 6.02±0.41(Predicted)
- color
- White to Off-White
- Stability
- Hygroscopic
- InChI
- InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
- InChIKey
- QKDHBVNJCZBTMR-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=C(F)C=C2F)C2=C(C=C(F)C(N3CCNC(C)C3)=C2)C(=O)C(C(O)=O)=C1
- FDA UNII
- 1 WZ12GTT67 · 1WZ12GTT67
- ATC code
- 1 MA05 · J01MA05
Chemistry & industry
Applications
DescriptionTemafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.
UsesAntibacterial (microbial DNA topoisomerase inhibitor).
UsesTemafloxacin is an antimicrobial quinolone drug.
Upstream & downstream products
Upstream raw materials
Suppliers33 total
北京华美互利生物化工010-56205725 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
Related reactions
0 records
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Compound notes
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