Basic information
- CAS
109552-15-0- Standard SMILES
NCCC(O)(P(=O)([O-])O)P(=O)([O-])O.O.O.O.O.O.[Na+].[Na+]- InChIKey
CZYWHNTUXNGDGR-UHFFFAOYSA-L- Molecular formula
- C3H19NNa2O12P2
- Average molar mass
- 369.11 g/mol
- Monoisotopic mass
- 369.0177876
Overview
Pamidronate disodium is a 1,1-bis(phosphonic acid).
Names & identifiers
- Preferred name
- Aredia
- IUPAC
- disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate;pentahydrate
- English name
- Disodium pamidronate
- Molecular formula
- C3H14NNaO8P2
- Molecular weight
- 277.08
Names & synonyms
109552-15-0ArediaDisodium pamidronate pentahydratePamidronate, Disodium SaltPamidronate disodium hydratedisodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate;pentahydrateDisodium dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate, pentahydrateMFCD01938386Pamidronic acid sodium salt pentahydratesodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogen phosphonate) pentahydratePamidronate disodium hydrate (JAN)PAMIDRONATE DISODIUM HYDRATE [JAN]
Show more names
PAMIDRONATE DISODIUMAMINOMUXGCP-23339Apamidronate，PADPAMIDRONATE SODIUMDisodium PamidroteDisodium pamidronatePamedronate disodium salt
UNII-8742T8ZQZAAredia (TN)Pamidronate disodium [USAN:USP:JAN]Disodium (3-amino-1-hydroxypropylidene)bisphosphonate pentahydrateDisodium-3-amino-1-hydroxypropylidene-1,1-diphosphonate pentahydratePamidronate disodium (USP)orb320440SCHEMBL506809
Properties
Computed structural properties
- Topological polar surface area
- 172 Ų
- Hydrogen bond donors
- 9
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 4
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 238
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- Soluble in water, practically insoluble in methylene chloride. It is sparingly soluble in dilute mineral acids and dissolves in dilute alkaline solutions.
- form
- White solid
- color
- White to off-white
- Water Solubility
- 10 mg/mL · water: 10mg/mL
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2
- InChIKey
- CZYWHNTUXNGDGR-UHFFFAOYSA-L
- SMILES
- [Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O
- CAS DataBase Reference
- 109552 · 109552-15-0(CAS DataBase Reference)
- FDA UNII
- 8742 T8ZQZA · 8742T8ZQZA
- NCI Dictionary of Cancer Terms
- Aredia; pamidronate disodium
- NCI Drug Dictionary
- Aredia
- UNSPSC Code
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- SZ6522666
- hs_code
- 2931909042
- Toxicity
- women,TDLo,intravenous,1200ug/kg (1.2mg/kg),BEHAVIORAL: ATAXIAMUSCULOSKELETAL: OTHER CHANGES,Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 719, 1997.
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H319
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2
- Precautionary statements
- P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Chemistry & industry
Applications
UsesPamidronate Disodium Salt Pentahydrate is a calcium metabolism regulator.
UsesBone resorption inhibitor.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Shanghai Yingrui Biopharma Co.,Ltd21-33585366 · [email protected]
武汉灵灵九生物科技有限公司15623309010 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
Baoji Guokang Healthchem co.,ltd
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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