Basic information
- CAS
59-97-2- Standard SMILES
Cl.c1ccc(CC2=NCCN2)cc1- InChIKey
RHTNTTODYGNRSP-UHFFFAOYSA-N- Molecular formula
- C10H13ClN2
- Average molar mass
- 196.67 g/mol
- Monoisotopic mass
- 196.0767261
Overview
Tolazoline hydrochloride is a member of benzenes.
Names & identifiers
- Preferred name
- Tolazoline Hydrochloride
- IUPAC
- 2-benzyl-4,5-dihydro-1H-imidazole;hydrochloride
- English name
- Tolazoline hydrochloride
- Molecular formula
- C10H13ClN2
- Molecular weight
- 196.68
Names & synonyms
Tolazoline hydrochloride59-97-2Tolazoline HClBenzazoline hydrochloride1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, monohydrochlorideDTXSID90217182-Benzyl-2-imidazoline monohydrochlorideTCMDC-125842NSC-757353E669Z6S1JGDTXCID001718Tolazine Injection
Show more names
tolavadLaMbralarterodyltolazolinechlorideTIMTEC-BB SBB000360Priscol hydrochloride2-BENZYL-2-IMIDAZOLINEimidalinehydrochlorideTolazolin hydrochloride
RefChem:56142Tolazoline Monohydrochloride200-447-3Benzidazol2-benzyl-4,5-dihydro-1H-imidazole hydrochloridePriscoline2-Benzyl-2-imidazoline hydrochloridePriscoline hydrochloride
Database identifiers
- CAS
59-97-2- PubChem CID
- 6048
- DTXSID
DTXSID9021718
Properties
Computed structural properties
- Topological polar surface area
- 24.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 2
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 169
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section135.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 172 · 172-176 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Crystalline Powder
- color
- White to almost white
- Sensitive
- Hygroscopic
- Merck
- 14 · 14,9506
- Stability
- Hygroscopic
- Major Application
- pharmaceutical (small molecule)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationTolazoline hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- tsca
- TSCA listed
- ridadr
- 2811
- hs_code
- 29332900
- Toxicity
- LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82
- risk_code
- 22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs used to cause dilation of the blood vessels.
Uses & manufacturing
General Manufacturing Information1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, hydrochloride (1:1): INACTIVE
Applications
Usesa-adrenergic antagonist. A peripheral vasodilator
UsesΑn α-adrenergic antagonist. A peripheral vasodilator.
Usesadrenergic blocker
Upstream & downstream products
Upstream raw materials
Suppliers100 total
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…