Basic information
- CAS
116209-55-3- Standard SMILES
CC(C)NC[C@H](O)COc1ccc(CCOCC2CC2)cc1.Cl- InChIKey
CHDPSNLJFOQTRK-LMOVPXPDSA-N- Molecular formula
- C18H30ClNO3
- Average molar mass
- 343.9 g/mol
- Monoisotopic mass
- 343.1914215
Overview
Levobetaxolol Hydrochloride is the hydrochloride salt form of levobetaxolol, the S-isomer of the -selective beta-1 adrenergic receptor antagonist betaxolol with anti-glaucoma activity and devoid of intrinsic sympathomimetic activity. When applied topically in the eye, levobetaxolol reduces aqueous humor secretion and lowers the intraocular pressure (IOP).
Names & identifiers
- Preferred name
- Levobetaxolol Hydrochloride
- IUPAC
- (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride
- English name
- Levobetaxolol HCL
- Molecular formula
- C18H29NO3.ClH
- Molecular weight
- 343.89
Names & synonyms
LEVOBETAXOLOL HYDROCHLORIDE116209-55-3Levobetaxolol HClBetaxonAL 1577A(S)-Betataxolol hydrochlorideAL1577AUNII-8MR4W4O06J8MR4W4O06JDTXSID20151321(-)-(S)-1-(p-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol hydrochloride2-Propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, hydrochloride, (2S)-
Show more names
Alvocidib Impurity 29Levobetaxolol HCL USP/EP/BPLevobetaxolol HCl (AL-1577A)(S)-BETAXOLOL HYDROCHLORIDEAL-1577ALevobetaxolol hydrochloride, 10 mM in DMSO1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)-2-propanol hydrochloride
2-PROPANOL, 1-(4-(2-(CYCLOPROPYLMETHOXY)ETHYL)PHENOXY)-3-((1-METHYLETHYL)AMINO)-, (2S)-, HYDROCHLORIDELEVOBETAXOLOL HYDROCHLORIDE (MART.)LEVOBETAXOLOL HYDROCHLORIDE [MART.]RefChem:56682DTXCID1073812Levobetaxolol hydrochloride [USAN]Levobetaxolol (hydrochloride)(S)-1-(4-(2-(CYCLOPROPYLMETHOXY)ETHYL)PHENOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL HYDROCHLORIDE
Properties
Computed structural properties
- Topological polar surface area
- 50.7 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 11
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 286
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 92 · 92-93 °C
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 10 · DMF:10.0(Max Conc. mg/mL);29.08(Max Conc. mM)DMSO:59.67(Max Conc. mg/mL);173.5(Max Conc. mM)Ethanol:35.0(Max Conc. mg/mL);101.78(Max Conc. mM)PBS (pH 7.2):10.0(Max Conc. mg/mL);29.08(Max Conc. mM)Water:47.0(Max Conc. mg/mL);136.67(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- FDA UNII
- 8 MR4W4O06J · 8MR4W4O06J
Chemistry & industry
Applications
UsesAnti-adrenergic (β-receptor).
Suppliers43 total
济南百隆化学有限公司[email protected] · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
深圳市洛克医药科技有限公司13128912434 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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